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  4. CD37 Recombinant Monoclonal Antibody

CD37 Recombinant Monoclonal Antibody

  • 中文名稱：
    CD37重組抗體
  • 貨號：
    CSB-RA004928MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA004928MA1HU diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA004928MA1HU CD37重組單克隆抗體是針對人源CD37抗原設計的高特異性科研工具。CD37作為四次跨膜蛋白家族成員，在B淋巴細胞表面特異性表達，參與調控細胞黏附、遷移及信號轉導，其異常表達與B細胞淋巴瘤等疾病密切相關。本抗體經ELISA及免疫組化（IHC）雙重平臺驗證，在IHC應用中可清晰顯示石蠟包埋組織中B淋巴細胞的膜定位特征，推薦使用稀釋度為1:50-1:200，能有效區分目標蛋白的組織分布差異。ELISA檢測體系顯示其具備出色的線性反應范圍，適用于體外樣本的定量分析。該產品可為B細胞發育分化研究、淋巴瘤微環境分析、免疫細胞表面標記物檢測等實驗提供可靠支持，尤其在探究B細胞相關疾病的分子機制、篩選潛在治療靶點及開發體外檢測方法等領域具有重要應用價值。通過嚴格的抗原親和純化工藝，確保批次間穩定性，適用于需要高重復性的長期研究項目。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD37 Recombinant Monoclonal Antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CD37 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    9H6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma. PMID: 27760757
    2. Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML). PMID: 25934707
    3. The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. PMID: 24445867
    4. Data indicate that enhanced antibody-dependent cell cytotoxicity (ADCC) is observed against chronic lymphocytic leukemia cells and is sustained at concentrations of SMIP-016(GV) as low at 5E(-6) microg/mL on cells expressing minimal CD37 antigen. PMID: 23883821
    5. Identify two tyrosine residues in tetraspanin CD37 directly mediating transduction of survival and apoptotic signals. PMID: 22624718
    6. In the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37- or Tssc6-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity. PMID: 20709950
    7. CD37 cross-linking on human T cells transduces signals that lead to complete inhibition of CD3-induced T cell proliferation. PMID: 14978098
    8. CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production. PMID: 17182550
    9. provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies PMID: 17440052

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  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Tetraspanin (TM4SF) family
  • 組織特異性：
    B-lymphocytes.
  • 數據庫鏈接：

    HGNC: 1666

    OMIM: 151523

    KEGG: hsa:951

    STRING: 9606.ENSP00000325708

    UniGene: Hs.166556



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