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CCR8 Recombinant Monoclonal Antibody

  • 中文名稱：
    CCR8重組抗體
  • 貨號：
    CSB-RA004847MA3HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Untransfected CHO-K1 cells surface(green line) and transfected Human CCR8 CHO-K1 stable cells surface (red line) were stained with anti-CCR8 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
    • The Binding Activity of CCR8 with Anti-CCR8 recombinant antibody.
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR8 (CSB-MP004847HU) at 5 μg/mL can bind Anti-CCR8 recombinant antibody, the EC50 is 11.20-15.63 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CCR8 Recombinant Monoclonal Antibody（CUSABIO貨號：CSB-RA004847MA3HU）是一種高特異性抗體，靶向趨化因子受體CCR8。CCR8是G蛋白偶聯(lián)受體家族成員，主要表達(dá)于調(diào)節(jié)性T細(xì)胞（Treg）和Th2細(xì)胞表面，參與免疫調(diào)節(jié)及炎癥反應(yīng)，在腫瘤微環(huán)境中的免疫逃逸機制研究中備受關(guān)注。本產(chǎn)品經(jīng)過流式細(xì)胞術(shù)（FC）嚴(yán)格驗證，可高效識別天然及過表達(dá)狀態(tài)下的CCR8蛋白，適用于活細(xì)胞或固定化樣本的表面標(biāo)記檢測。其高靈敏度和低背景特性確保在復(fù)雜樣本（如腫瘤浸潤淋巴細(xì)胞或炎癥模型細(xì)胞）中精準(zhǔn)定位CCR8的表達(dá)分布。該抗體適用于腫瘤免疫學(xué)、自身免疫性疾病及過敏反應(yīng)等領(lǐng)域的機制研究，例如Treg細(xì)胞功能分析、腫瘤免疫微環(huán)境解析或Th2型免疫應(yīng)答調(diào)控實驗，為探索CCR8在免疫抑制通路中的作用提供可靠工具。本品為重組單克隆抗體，批間一致性穩(wěn)定，僅限科學(xué)研究使用。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CCR8; CKRL1; CMKBR8; CMKBRL2; C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CC chemokine receptor CHEMR1; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1; CD antigen CDw198
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CCR8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6B12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
  • 基因功能參考文獻(xiàn)：
    1. Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery. PMID: 28533380
    2. Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. PMID: 27226537
    3. High CCR8 expression is associated with high recurrence in kidney cancer. PMID: 26716905
    4. findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease PMID: 25390351
    5. Epidermal-derived vitamin D3 metabolites and prostaglandins provide an essential cue for the localization of CCR8+ immune surveillance T cells within healthy human skin. PMID: 26002980
    6. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis. PMID: 23811304
    7. Identification of human CCR8 as a CCL18 receptor. PMID: 23999500
    8. CCR8(+) myeloid cell subset is expanded in patients with cancer. PMID: 23363815
    9. Data show that CCR8 expression by newly activated naive T cells is regulated by skin-specific factor(s) derived primarily from epidermal keratinocytes. PMID: 23043070
    10. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID: 22479563
    11. The functional data from human macrophages suggest a potential cross talk between the CCR8 and the Toll-like receptor 4 (TLR4) pathways, both of which are present in chronic obstructive pulmonary disease patients. PMID: 21976223
    12. There may be a role for CCR8 in the recruitment of T cells to the lung in asthmatics. PMID: 20455898
    13. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway PMID: 12525579
    14. found in the central nervous system and is associated with phagocytic macrophages PMID: 12547701
    15. CCR8 genes and surrounding genomic regions these genes are the result of the duplication of an ancestral gene prior to the divergence of teleost fish. PMID: 12551893
    16. Transfected human CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. PMID: 12645948
    17. The induction of CCR8 under conditions associated with vascular smooth muscle cell proliferation and migration raises the possibility that CCR8 may play an important role in vessel wall pathology. PMID: 14576057
    18. the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation PMID: 15814739
    19. CCR8 ligands are allotropic, binding to distinct sites within CCR8; the human immune system may have evolved to use CCL7 as a selective antagonist of viral chemokine activity at CCR8 but not those of the host ligand PMID: 17023422
    20. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID: 17082609
    21. CCR8-expressing CD4-positive T lymphocytes are preferentially recruited from the periphery into the lungs of asthmatic individuals, driven by elevated CCL1 levels produced almost exclusively by mast cells and basophils. PMID: 17641040
    22. The combination of 17beta-E(2) with the environmental pollutant TCDD is involved in the pathogenesis of endometriosis via up-regulating the chemokine CCR8-I-309. PMID: 17693327

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1609

    OMIM: 601834

    KEGG: hsa:1237

    STRING: 9606.ENSP00000326432

    UniGene: Hs.113222



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