在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

BRD2 Recombinant Monoclonal Antibody

  • 中文名稱:
    BRD2 Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA972223A0HU
  • 規格:
    ¥1320
  • 圖片:
    • Overlay Peak curve showing Hela cells stained with CSB-RA972223A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Bromodomain-containing protein 2 (O27.1.1) (Really interesting new gene 3 protein), BRD2, KIAA9001 RING3
  • 反應種屬:
    Human
  • 免疫原:
    A synthesized peptide from human BRD2 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    3C6
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, FC
  • 推薦稀釋比:
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in spermatogenesis or folliculogenesis. Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
  • 基因功能參考文獻:
    1. The results of the present study show evidence that BRD2 promoter methylation variation is a cause of juvenile myoclonic epilepsy in Caucasians PMID: 29608786
    2. acetylated peptide selectivity between human BET Brd2 bromodomains BD-I and BD-II in glioblastoma PMID: 29956673
    3. In pluripotent cells, Brd2-Brd4 occupy Nodal gene regulatory elements (NREs), but only Brd4 is required for pluripotency gene expression. Brd4 downregulation facilitates pluripotent exit and drives enhanced Brd2 NRE occupancy, thereby unveiling a specific function for Brd2 in differentiative Nodal-Smad2 signalling PMID: 28588073
    4. BRDs are overexpressed in castration-resistant prostate cancer and that ATAD2 and BRD2 have prognostic value. PMID: 28591577
    5. The bromodomain and extraterminal domain (BET) family consists of BRDT, BRD2, BRD3, and BRD4, each containing 2 bromodomains located N-terminal to extraterminal domain, which is located near C-terminus. Data suggest that 10 distinct acylations participate in binding of BET family proteins to histone 4 (oligopeptide fragments used here); C-terminal bromodomains do not cooperatively bind multiple acylation sites. PMID: 28945351
    6. The identification of RNF43 mutations in a distinct subset of intraductal papillary neoplasm of the bile ducts revealed a new molecular role in the pathogenesis of this disease PMID: 27864998
    7. LRP1B, BRD2 and CACNA1D are new candidate genes in fetal metabolic programming of newborns exposed to maternal hyperglycemia. PMID: 26586120
    8. This study implicates BET Brds as important regulators of IkappaB kinase/NF-kappaB-mediated synovial inflammation of RA and identifies BET proteins as novel therapeutic targets in inflammatory arthritis. PMID: 26324948
    9. An unexpected role for the bromodomain and extraterminal domain (BET) proteins BRD2 and BRD4 in maintaining oncogenic IKK activity in activated B-cell-like diffuse large B-cell lymphoma. PMID: 25049379
    10. BET proteins, particularly Brd2 and Brd4, may play a key role in the regulation of Nrf2-dependent antioxidant gene transcription and are hence an important target for augmenting antioxidant responses in oxidative stress-mediated diseases. PMID: 24733848
    11. The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing. PMID: 24048450
    12. A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins. PMID: 24146614
    13. The SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myoclonic epilepsy' PMID: 23756480
    14. BRD2, BRD3, and BRD4 interact with gammaretroviral INs and serve as cofactors for murine leukemia virus integration. PMID: 24049186
    15. our results identify BRD2 as a new Tat-independent suppressor of HIV transcription in latently infected cells and underscore the therapeutic potential of BET inhibitors in the reversal of HIV latency. PMID: 23255218
    16. Brd2 and Brd4 proteins mediatE the responses of LFs after growth factor stimulation and drivE the induction of lung fibrosis in mice in response to bleomycin challenge. PMID: 23115324
    17. Our study did not confirm the presence of the genetic variants previously found to link the BRD2 gene to the idiopathic form of photosensitive epilepsy. PMID: 22766109
    18. The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels. PMID: 21608014
    19. The BRDT gene was not expressed in testicular tissue from patients with Sertoli cells only, whereas the other three genes of the BET family retained expression in all the sperm pathologies. PMID: 22035730
    20. the crystal structure of the second bromodomain of BRD2 (BRD2-BD2) in complex with the di-acetylated histone H4 tail (H4K5ac/K12ac) was shown. PMID: 20709061
    21. Data report the crystal structures of the N-terminal bromodomain of human BRD2 (BRD2-BD1; residues 74-194) in complex with each of three different Lys-12-acetylated histone H4 peptides. PMID: 20048151
    22. Studies indicate that KSHV LANA interacts with Brd2 and Brd4. PMID: 20036832
    23. no difference was observed in the allele and genotype frequencies of BRD2 between juvenile myoclonic epilepsy (JME) and controls PMID: 19953286
    24. immunoblot and immunoprecipitation experiments to identify proteins interacting with Fsrg1 and RING3 PMID: 12145330
    25. highly significant linkage disequilibrium between juvenile myoclonic epilepsy and a core haplotype of five single-nucleotide-polymorphism and microsatellite markers in chromosomal region 6p21 PMID: 12830434
    26. Evidence from transgenic mice suggests that Brd2 transactivates the cyclin A locus, and that overexpression increases cyclin A transcription, destabilizing the cell cycle. PMID: 16512664
    27. Present results support evidence that photoparoxysmal response and Myoclonic Epilepsy, Juvenile share epileptogenic pathways, for which BRD2 might be an underlying susceptibility gene. PMID: 16516380
    28. The results showed that BRD7 could interact with BRD2 and the region from amino acid 430 to 798 of BRD2 was critical for the interaction of BRD2 with BRD7. BRD2 mainly localizes in nucleus and BRD2 has distinct roles in initiating apoptosis. PMID: 16786191
    29. there are distinct functional roles for the two bromodomain proteins RING3/Brd2 and Brd4 in LANA binding PMID: 16940503
    30. Two acetyllysine-binding pockets and a negatively charged secondary binding pocket, produced at the dimer interface in BRD2 bromodomain 1 (BD1), may be the unique features that allow BRD2 BD1 to selectively bind to the acetylated histone H4 tail. PMID: 17148447
    31. Brd2 bromodomain 2 is monomeric in solution and dynamically interacts with H4-AcK12; additional secondary elements in the long ZA loop may be a common characteristic of BET bromodomains. PMID: 17848202
    32. study investigated the SNP markers (rs188254, rs206781, and rs516535) in the 3'-end of the BRD2 and found no significant difference between the allele frequencies in epilepsy cases and controls PMID: 17999746
    33. Results report that the double bromodomain proteins Brd2 and Brd3 associate preferentially in vivo with hyperacetylated chromatin along the entire lengths of transcribed genes. PMID: 18406326
    34. Brd2 is a novel protein kinase that plays a role in cell cycle-responsive transcription, recruiting E2F1, TATA Box Binding Protein and histone acetylase activity to E2F-responsive promoters in response to mitogenic stimuli. PMID: 17111193
    35. Brd2 associates with the transcription factor E2F, the Mediator components CDK8 and TRAP220, RNA polymerase II on chromatin; and associates with acetylated histone H4 through its bromodomains. PMID: 17148447
    36. The second bromodomain of Brd2 binds histone H4 acetyl-lysine K12. PMID: 17848202
    37. The BRD2 gene is located within the human class II major histocompatibility complex at Chromosome 6p21.3, but appears to have no role in antigen processing, and is likely involved in signal transduction and transcription. PMID: 11983150
    38. The BRD2 gene is homologous to the mammalian cell cycle regulator TAFII250 and the Drosophila trithorax group gene female sterile homeotic; the gene encodes a nuclear-localized kinase with signal transduction activity. PMID: 8595877
    39. Brd2-driven B cell lymphomas exhibit a transcriptional signature of diffuse large B cell lymphoma, and show differential expression of genes involved in normal proliferation, as well as several novel, tumor-specific genes. PMID: 17166848
    40. Brd2, a nuclear-localized protein kinase, binds to cyclin A promoter chromatin and recruits histone H4-specific acetylase activity, increasing cyclin A transcription and accelerating S phase entry in fibroblasts. PMID: 15548137
    41. B cell-restricted expression of Brd2 in transgenic mice upregulates cyclin A trancription even in mitogenically unstimulated B cells and causes lymphoma with a B1a-like immunophenotype, accompanied by peripheral B cell leukemia. PMID: 14563639
    42. Mitogenic stimuli induce nuclear localization of Brd2 protein. PMID: 10934046
    43. Brd2 protein participates in a nuclear complex that contains E2Fs. Overexpression of Brd2 protein with oncogenic ras transactivates E2F-dependent promoters of the cell cycle regulatory genes dihydrofolate reductase, cyclin D1, cyclin A and cyclin E. PMID: 10965846

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Detected on chromatin and nucleosomes.
  • 數據庫鏈接:

    HGNC: 1103

    OMIM: 601540

    KEGG: hsa:6046

    STRING: 9606.ENSP00000378702

    UniGene: Hs.734797



主站蜘蛛池模板: 亚洲欧美日韩成人一区二区三区| 亚洲午夜未满十八勿入网站| 99久久亚洲精品无码毛片| 高中生自慰www网站| 欧美熟妇的性裸交| 久草热8精品视频在线观看| 开心色怡人综合网站| 国产欧美va天堂在线观看视频下载 | 国产又色又爽又黄的免费| 午夜免费啪视频| 人妻少妇精品视频无码综合| 一本大道东京热无码视频| 国产精品亚洲色婷婷99久久精品 | 日本老妇人乱xxy| 欧洲日本一线二线三线区本庄铃 | 亚洲 欧美 另类图片| 欧美大片欧美激情性色a∨在线| 久久婷婷成人综合色综合| 欧美性受xxxx黑人xyx性爽| 亚洲国产欧美一区二区好看电影| 欧美国产亚洲日韩在线二区| 性按摩玩人妻hd中文字幕| 国模大胆一区二区三区| 亚洲精品卡2卡三卡4卡2卡乱码| 亚洲成a人片在线观看天堂无码不卡 | 最近免费中文字幕大全免费版视频| 97人人添人澡人人爽超碰| 成人av无码国产在线观看| 国产精品自产拍在线观看| 亚洲欧美日韩成人综合一区| 熟女丝袜潮喷内裤视频网站| 国产裸体美女永久免费无遮挡| 荫蒂添的好舒服视频囗交| 久久天堂av综合合色蜜桃网| 日韩精品 中文字幕 视频在线| 野狼av午夜福利在线| 国产乱人伦av在线a更新| 情侣激情18内射骚话国产| 日韩a∨精品日韩在线观看| 欧美金妇欧美乱妇xxxx| 欧美成妇人吹潮在线播放|