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BAG2 Recombinant Monoclonal Antibody

  • 中文名稱:
    BAG2 Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA104772A0HU
  • 規格:
    ¥1320
  • 圖片:
    • Western Blot
      Positive WB detected in: Hela whole cell lysate(30μg), Jurkat whole cell lysate(30μg), PC-3 whole cell lysate(30μg)
      All lanes: BAG2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 24 kDa
      Observed band size: 24 kDa
      Exposure time:1min
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2), BAG2
  • 反應種屬:
    Human
  • 免疫原:
    A synthesized peptide from human BAG2 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    11B5
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.
  • 基因功能參考文獻:
    1. the nucleotide exchange factor (NEF) Bag2 stimulates SV40 release from Hsc70, thereby enabling successful virus arrival at the cytosol, which leads to infection. Hsp105, another NEF of Hsc70, displays a function overlapping that of Bag2, underscoring the importance of this release reaction. PMID: 29769335
    2. A comprehensive review of the structure, functions, and protein interactions of BAG2 PMID: 28536620
    3. Data show that BAG2 Inhibits CHIP-Mediated HSP72 ubiquitination in aged cells. PMID: 28042827
    4. repression of BAG2 expression or BAG2 activity by cold-sensitive pathways, as modeled in undifferentiated and differentiated cells, respectively, may be a causal factor in the accumulation of cytotoxic hyperphosphorylated tau protein. PMID: 26208804
    5. NF-kappaB-mediated modulation of BAG2 expression regulates the shift between the neurotrophic and neurotoxic effects of Abeta1-42. PMID: 25985852
    6. Thus, BAG2 promotes mutant p53 accumulation and gain-of-function in tumor growth, metastasis and chemoresistance. PMID: 26271008
    7. This study showed that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise pathogenic ataxin3-80Q by inhibiting its ubiquitination PMID: 25006867
    8. this data correlate BAG2 to PINK1 for the first time, strengthening the important role of BAG2 in Parkinson disease -related neurodegeneration. PMID: 24383081
    9. BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP PMID: 16169850
    10. The activity of BAG-2 resembles that of the previously characterized Hsc70 cochaperone and CHIP inhibitor HspBP1. PMID: 16207813

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  • 數據庫鏈接:

    HGNC: 938

    OMIM: 603882

    KEGG: hsa:9532

    STRING: 9606.ENSP00000359727

    UniGene: Hs.745046



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