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sep-1 Antibody

  • 中文名稱：
    sep-1 Antibody
  • 貨號：
    CSB-PA271022XA01CXY
  • 規格：
    ￥880
  • 圖片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes: sep-1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 35 kDa
      Observed band size: 35 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Caenorhabditis elegans sep-1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    sep-1
  • 別名：
    Separin homolog sep-1 (EC 3.4.22.49) (Separase) sep-1 Y47G6A.12
  • 宿主：
    Rabbit
  • 反應種屬：
    Caenorhabditis elegans
  • 免疫原：
    Recombinant Caenorhabditis elegans sep-1 protein (160-215aa)
  • 免疫原種屬：
    Caenorhabditis elegans
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase. May cleave histone H3-like protein cpar-1 during meiosis I metaphase-anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating rab-11-positive vesicle trafficking at the plasma membrane at the cleavage furrow and midbody. Regulates centriole segregation during spermatocyte meiosis. Required for embryonic anterior-posterior axis formation.
  • 基因功能參考文獻：
    1. Data indicate that protein phosphatase 5 is an important regulator of separase. PMID: 29246899
    2. These findings suggest that separase cleaves an unknown substrate to promote the exocytosis of RAB-11 vesicles and paves the way for biochemical identification of substrates. PMID: 28820333
    3. single-particle cryo-electron microscopy (cryo-EM) was used to determine a near-atomic-resolution structure of the Caenorhabditis elegans separase-securin complex. PMID: 28263324
    4. Examination of the N-terminal tail sequence of CPAR-1 revealed a putative separase cleavage site and mutation of the signature residues in this site eliminated the cleavage reaction. PMID: 25919583
    5. separase is required for cytokinesis by regulating the incorporation of RAB-11-positive vesicles into the plasma membrane at the cleavage furrow and midbody PMID: 20116245
    6. SEP-1 has two separable yet coordinated functions: to regulate cortical granule exocytosis and to mediate chromosome separation PMID: 17913784

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  • 亞細胞定位：
    Cytoplasm. Chromosome. Cytoplasmic granule. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody.
  • 組織特異性：
    Expressed in oocytes. Expressed in male germline. Expressed in spermatocytes but undetectable in spermatids (at protein level).
  • 數據庫鏈接：


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