在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

pop-1 Antibody

  • 中文名稱:
    pop-1兔多克隆抗體
  • 貨號:
    CSB-PA606015XA01CXY
  • 規格:
    ¥880
  • 圖片:
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:pop-1 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 20 kDa
      Observed band size: 20 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Caenorhabditis elegans pop-1 Antibody Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    pop-1 Antibody
  • 別名:
    Protein pop-1 (Posterior pharynx defect protein 1) pop-1 W10C8.2
  • 宿主:
    Rabbit
  • 反應種屬:
    Caenorhabditis elegans
  • 免疫原:
    Recombinant Caenorhabditis elegans pop-1 protein (60-221aa)
  • 免疫原種屬:
    Caenorhabditis elegans
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Similarly, involved in asymmetrical division of seam cells, a stem cell-like lineage. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors.
  • 基因功能參考文獻:
    1. these results indicate that SYS-1 and POP-1 levels are influenced by the parent cell's SYS-1/POP-1 levels and this may provide an additional mechanism by which POP-1 regulates distinct targets in different developmental contexts. PMID: 26488501
    2. we demonstrate that POP-1 (the C. elegans TCF) also activates target genes through HMG and Helper site interactions. PMID: 24516405
    3. SYS-1 and POP-1 nuclear levels are regulated in opposite directions; the C terminus of POP-1 is essential for LIT-1 phosphorylation and is specifically bound by the diverged beta-catenin WRM-1 PMID: 21852394
    4. Animals with reduced function of the Wnt-pathway downstream effector POP-1 have as many as 67 seam cells. The 'Wnt/beta-catenin asymmetry' pathway is required for the proper stem cell-like asymmetric division of seam cells. PMID: 20849842
    5. Study suggests that pop-1 is not critical for mesoderm specification beyond repression of endoderm specification, and reveals that Wnt-modified pop-1 further reinforces endoderm specification by repressing mesoderm fate in endoderm. PMID: 19818340
    6. acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans LEF/TCF homolog, through increasing nuclear import and blocking nuclear export PMID: 12651889
    7. Wnt/MAPK signaling downregulates POP-1 levels in responsive cells, in part by increasing nuclear LIT-1 levels, thereby increasing POP-1 phosphorylation and PAR-5-mediated nuclear export. PMID: 15066285
    8. The Wnt effector POP-1 and the PAL-1/Caudal homeoprotein collaborate with SKN-1 to activate C. elegans endoderm development. PMID: 16084508
    9. TCF protein, POP-1, converts from repressor to activator as a result of Wnt-induced lowering of nuclear levels. PMID: 16112103
    10. POP-1/TCF and SYS-1/beta-catenin directly activate transcription of ceh-22/nkx2.5 isoforms in somatic gonadal precursor distal daughter cells. PMID: 16461282
    11. The Wnt effector POP-1, its coactivator SYS-1/beta-catenin, and of upstream components including beta-catenin WRM-1 causes all SGP daughters to adopt the proximal fate. PMID: 16890160
    12. Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. PMID: 17296929
    13. There are two genetic pathways, one increasing SYS-1 and the other decreasing POP-1 levels, robustly elevate the SYS-1-to-POP-1 ratio in the posterior cell, thereby driving A-P differential cell fates. PMID: 17567664
    14. Integration of Wnt-dependent and Wnt-independent cell fate specification pathways within the Caenorhabditis genus can occur in different ways. PMID: 18977344

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    TCF/LEF family
  • 數據庫鏈接:

    KEGG: cel:CELE_W10C8.2

    STRING: 6239.W10C8.2

    UniGene: Cel.19670



主站蜘蛛池模板: 成人欧美一区二区三区视频| 国产精品亚洲精品日韩已满十八小 | 中国极品少妇videossexhd| 摸丰满大乳奶水www免费| 久久久亚洲欧洲日产国码αv| 中文字幕亂倫免賛視頻| 黑人巨大精品欧美一区二区免费| 亚洲精品国产精华液| 婷婷色香合缴缴情av第三区| 国产激情综合在线看| 蜜桃av噜噜一区二区三区| 成年女性特黄午夜视频免费看| 狠狠色丁香婷婷综合| 亚洲国产中文曰韩丝袜 | 国产美女牲交视频| 国产午夜三级一区二区三| 色欲天天天综合网| 亚洲欧美日韩综合久久久久久| 国产又色又爽又黄刺激在线视频| 久久中文字幕人妻av熟女| 东京热加勒比视频一区| 亚洲精品无码久久久| 美女国产毛片a区内射| 亚洲欧美国产双大乳头| 香蕉在线 亚洲 欧美 专区 | 免费观看全黄做爰的视频| 久久国产福利一区二区| 很黄很色60分钟在线观看| 好爽…又高潮了毛片免费看| 香蕉在线精品视频在线| 亚洲狠狠爱综合影院网页| 欧洲美女粗暴牲交免费观看| 乱子轮熟睡1区| 国产在线码观看超清无码视频| 熟女乱亚洲图| 2020无码专区人妻系列日韩| 久久一本久综合久久爱| 丰满少妇做爰视频爽爽和| 国产成人久久精品77777综合 | 免费人成在线观看视频播放| 国产国产久热这里只有精品|