在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

inhA Antibody, FITC conjugated

Rare Species
  • 中文名稱:
    inhA兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA363781HC01MVZ
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mycobacterium tuberculosis inhA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    inhA
  • 別名:
    inhA antibody; Rv1484 antibody; MTCY277.05 antibody; Enoyl-[acyl-carrier-protein] reductase [NADH] antibody; ENR antibody; Enoyl-ACP reductase antibody; EC 1.3.1.9 antibody; FAS-II enoyl-ACP reductase antibody; NADH-dependent 2-trans-enoyl-ACP reductase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mycobacterium tuberculosis
  • 免疫原:
    Recombinant Mycobacterium tuberculosis Enoyl-[acyl-carrier-protein] reductase [NADH] protein (1-269AA)
  • 免疫原種屬:
    Mycobacterium tuberculosis
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls. Catalyzes the NADH-dependent reduction of the double bond of 2-trans-enoyl-[acyl-carrier protein], an essential step in the fatty acid elongation cycle of the FAS-II pathway. Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates. The mycobacterial FAS-II system utilizes the products of the FAS-I system as primers to extend fatty acyl chain lengths up to C56, forming the meromycolate chain that serves as the precursor for final mycolic acids.; Is the primary target of the first-line antitubercular drug isoniazid (INH) and of the second-line drug ethionamide (ETH). Overexpressed inhA confers INH and ETH resistance to M.tuberculosis. The mechanism of isoniazid action against InhA is covalent attachment of the activated form of the drug to the nicotinamide ring of NAD and binding of the INH-NAD adduct to the active site of InhA. Similarly, the ETH-NAD adduct binds InhA.
  • 基因功能參考文獻:
    1. Out of the 141 isolates studied, 3 (2.1%) were found carrying mutations in the katG gene that confer resistance to Isoniazid (INH). No mutations were detected in the inhA promoter region gene that confer weak INH resistance or in the rpoB gene that confer Rifampicin resistance. PMID: 29868151
    2. Molecular dynamics (MD) simulation show that EN and N1 remained in the binding pocket similar to the docked pose of EN-InhA and E1-InhA complexes and also suggested that InhA binds to its inhibitor in inhibitor-induced folding manner. Our study concludes that multiple receptor conformers based molecular docking can be an alternative to study the effect of receptor flexibility in ligand binding PMID: 28957755
    3. Virtually Designed Triclosan-Based Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis and of Plasmodium falciparum. PMID: 27490275
    4. Structural analysis of InhA provided the crucial points to enhance the NADH binding affinity towards InhA mutants in the presence of direct InhA inhibitors to combat isoniazid drug resistance. PMID: 26658674
    5. InhA gene mutation is associated with isoniazid resistance in Mycobacterium tuberculosis. PMID: 25799046
    6. The specific zone mutations in inhA gene for rifampicin and isoniazid were investigated with molecular methods in isolated unique PMID: 26506671
    7. Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA. PMID: 26147157
    8. The study reports empirical parameters to differentiate the 'open' and 'closed' conformation of substrate-binding loop by comprehensive ana-lysis of InhA crystal structures. PMID: 24895891
    9. The results reveal that the presence of a mutation in the inhA regulatory region together with a mutation in the inhA coding region can lead to the development of high-level isoniazid resistance and cross-resistance to ethionamide among the MDR-TB strains circulating in Lisbon. PMID: 23539241
    10. No mutation was observed in the inhA promotor region or in the INH sensitive control isolate (H37Rv). PMID: 22358357
    11. We chose to search for new inhibitors of the enoyl-acyl carrier protein reductase InhA, the target of the first-line TB drug isoniazid. Two compounds (CD39 and CD117) were bactericidal against drug-susceptible and drug-resistant M. tuberculosis. PMID: 21628538
    12. inhA promoter mutations are strongly associated with extensively drug-resistant-tuberculosis in South Africa PMID: 21333101
    13. Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. PMID: 21143326
    14. InhA phosphorylation is an important event in regulating cell growth. PMID: 20864541
    15. inhA(S94A) allele confers clinically relevant levels of resistance to isoniazid killing & inhibition of mycolic acid synthesis. decreased binding of INH-NAD inhibitor to InhA establishes InhA as primary target of isoniazid action in M. tuberculosis. PMID: 16906155
    16. catalysis of substrate reduction by InhA results, in part, from correct orientation of the cofactor in the ground state PMID: 17472376
    17. T (-8)C of inhA mutations was found in multidrug resistant Mycobacterium tuberculosis isolates. PMID: 17539290
    18. The structure of two InhA mutants (I21V and S94A), identified in INH-resistant clinical isolates, were solved. PMID: 17588773
    19. inhibited by Anthecotulide from Anthemis auriculata PMID: 18424102

    顯示更多

    收起更多

  • 蛋白家族:
    Short-chain dehydrogenases/reductases (SDR) family, FabI subfamily
  • 數據庫鏈接:

    KEGG: mtu:Rv1484

    STRING: 83332.Rv1484



主站蜘蛛池模板: 桃花综合久久久久久久久久网| a亚洲va欧美va国产综合| 一本之道高清无码视频| 成人免费看黄网站yyy456| av在线 高清不卡区| 亚洲人成网77777亚洲色| 国产亚洲精品字幕在线观看| 少妇粉嫩小泬喷水视频| 精品自拍亚洲一区在线| 亚洲综合另类小说色区| 欧美人与禽z0zo牲伦交| 国产亚洲精品久久无码98| 国产成人久久精品77777综合 | 中文在线最新版天堂| 午夜免费国产体验区免费的 | 国产色欲色欱www在线| 人人爽人人澡人人人人妻| 成人无码精品1区2区3区免费看| 国产成人无码精品午夜福利a| 欧美品无码一区二区三区在线蜜桃| 韩国国内大量揄拍精品视频| 丰满熟女人妻一区二区三| 性色av极品无码专区亚洲| 亚洲中文有码字幕日本第一页| 精品一区国产vr| 精品国产av 无码一区二区三区 | 久久五月精品中文字幕| 精品玖玖玖视频在线观看| 国产999久久高清免费观看| 国产av人人夜夜澡人人爽麻豆 | 十八岁污网站在线观看| 亚洲成在人线在线播放无码vr| 久久久久av无码免费网| 国产成人亚洲综合无码精品| 亚洲 欧美 另类图片| 成人性做爰aaa片免费看| 国产美女视频免费观看的网站| 忘忧草影院在线www韩国日本| 日韩激情无码不卡码| 日本丰满少妇xxxx| 亚洲国产av无码一区二区三区 |