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  4. cyp26b1 Antibody, Biotin conjugated

cyp26b1 Antibody, Biotin conjugated

Rare Species
  • 中文名稱：
    cyp26b1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA721935LD01DIL
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) cyp26b1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    cyp26b1
  • 別名：
    cyp26b1Cytochrome P450 26B1 antibody; Cyp26B1 antibody; EC 1.14.13.- antibody; Retinoic acid-metabolizing cytochrome antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Zebrafish
  • 免疫原：
    Recombinant Zebrafish Cytochrome P450 26B1 protein (366-511AA)
  • 免疫原種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development.
  • 基因功能參考文獻：
    1. we find that Cyp26 function is required in a short time window that overlaps the dynamic window of tenoblast condensation. However, cyp26b1 expression is largely restricted to regions between tenoblast condensations during this time PMID: 29227993
    2. The data demonstrate that RA-induced osteoblast-preosteocyte transitioning has multiple effects on developing bone in Cyp26b1 mutants, ranging from gain to loss of bone, depending on the allelic strength, the developmental stage and the cellular context. PMID: 26903503
    3. cyp26b1 is involved in limiting the activity of retinoic acid. Zygotic cyp26b1 was localized to presumptive rhombomere 3 and rhombomere 4 at early two-somite (2S) stage. Expression expands anteriorly to include rhombomere 2 at the 10S stage. PMID: 15661642
    4. effects of the inhibitor rather than excess retinoic acid most closely phenocopied the jaw defects seen with the Cyp26B1 morpholino PMID: 17616924
    5. Cyp26b1 is expressed within osteoblast cells, demonstrating that retinoic acid levels within these cells need to be tightly controlled PMID: 18927155
    6. cyp26b1 mutants may serve as a model to study the etiology of human vertebral disorders such as Klippel-Feil anomaly PMID: 18927157

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 數據庫鏈接：


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