在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

botB Antibody, HRP conjugated

Rare Species
  • 中文名稱:
    botB兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA318083LB01CLQ
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Clostridium botulinum botB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    botB
  • 別名:
    botBBotulinum neurotoxin type B antibody; BoNT/B antibody; Bontoxilysin-B) [Cleaved into: Botulinum neurotoxin B light chain antibody; LC antibody; EC 3.4.24.69); Botulinum neurotoxin B heavy chain antibody; HC)] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Clostridium botulinum
  • 免疫原:
    Recombinant Clostridium botulinum Botulinum neurotoxin type B protein (1-427AA)
  • 免疫原種屬:
    Clostridium botulinum
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin B which has 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell membrane during neurotransmitter release, when the toxin heavy chain (HC) binds to them. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the HC forms pores that allows the light chain (LC) to translocate into the cytosol. Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter release. Binds to host peripheral neuronal presynaptic membranes via synaptotagmins 1 and 2 (SYT1 and SYT2). Toxin binds to the membrane proximal extra-cytoplasmic region of host SYT1 and SYT2 that is transiently exposed outside of cells during exocytosis; exogenous gangliosides enhance binding and subsequent uptake of toxin into host cells. Toxin uptake into neural cells requires stimulation (incubation with K(+) to stimulate SYT protein receptor exposure); subsequently the toxin colocalizes with its receptor in host cells with a concomitant decrease in target protein (synaptobrevin-2/VAMP2) immunoreactivity. Toxin uptake can be blocked by the appropriate synaptotagmin protein fragments and gangliosides in cell culture and in mice. BoNT/B is a 'coincidence detector'; it requires simultaneous binding to coreceptor GT1b and low pH to transform into a membrane-bound, oligomeric channel. Whole toxin only has protease activity after reduction which releases LC.; Has proteolytic activity. After translocation into the eukaryotic host cytosol, inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2/VAMP2, blocking neurotransmitter release. In vitro the LC only has protease activity after reduction.; Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of light chain (LC) into host cytosol. Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD). The N-terminus of the TD wraps an extended belt around the perimeter of the LC; it does not seem to protect the active site, but might prevent premature LC dissociation from the translocation channel and protect toxin prior to translocation. Has 2 coreceptors; complex gangliosides found primarily on neural tissue and host synaptotagmin-1 and -2 (SYT1 and SYT2) which bind simultaneously to adjacent but separate sites at the tip of the HC. HC alone partially prevents uptake of whole toxin by neural cells, and delays paralysis onset by 160%. Binding probably positions the TD for integration into the synaptic vesicle membrane. The HC forms channels at low pH that mediate transport of the light chain (LC) from the endocytic vesicle to the cytosol. Binds gangliosides GD1b and GT1b. Gangliosides are not only a coreceptor, but also required for uptake into nerve cells. HC alone binds to host receptor proteins SYT1 and SYT2. Interaction with SYT1 protein does not require SYT1 glycosylation. The HC C-terminus (approximately residues 1079-1291) interacts with host SYT2. Has higher affinity for SYT2 than SYT1. Significantly decreases uptake and toxicity of whole BoNT/B and BoNT/G.
  • 亞細胞定位:
    [Botulinum neurotoxin type B]: Secreted. Host cell junction, host synapse, host presynaptic cell membrane.; [Botulinum neurotoxin B light chain]: Secreted. Host cytoplasm, host cytosol.; [Botulinum neurotoxin B heavy chain]: Secreted. Host cell junction, host synapse, host presynaptic cell membrane. Host cytoplasmic vesicle, host secretory vesicle, host synaptic vesicle membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Peptidase M27 family


主站蜘蛛池模板: 男女啪啪永久免费观看网站| 国产成人毛片在线视频软件 | 人牛交vide欧美xxxx| 亚洲最新无码成av人| 成人a片产无码免费视频在线观看| 女人19水真多免费毛片| 手机国产乱子伦精品视频| 久久人人爽天天玩人人妻精品 | 亚洲国产精品嫩草影院| 色综合久久中文综合网| 亚欧无线一线二线三线区别| 午夜无码性爽快影院6080| 亚洲成a∧人片在线播放调教| 国产亚洲精品精品国产亚洲综合| 中文成人在线| 国产精品亚洲精品日韩己满十八小| 亚洲中文字幕久久精品蜜桃| 国产丰满人妻一区二区| 一本色道久久99一综合| 国产精品自在线拍国产手机版| 精品国产一区二区三区四区在线看 | 国产精品免费视频色拍拍| 亚洲国产欧美在线人成app | 国模冰莲极品自慰人体 | 2020年国产精品| 久久精品国产日本波多野结衣 | 2020年无码国产精品高清免费| 久久久久蜜桃精品成人片公司| 精品熟女日韩中文十区| 久久九九av免费精品| 五月丁香六月激情综合在线视频 | 国产黄在线观看免费观看不卡| 免费国产va在线观看中文字 | 国产精品人成电影在线观看| 人妻丰满熟av无码区hd| 日本高清在线一区二区三区| 2020精品自拍视频曝光| 日本日本乱码伦专区| 性欧美老妇另类xxxx| 国产亚洲婷婷香蕉久久精品| 人人妻人人藻人人爽欧美一区 |