在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ZRANB3 Antibody

ZRANB3 Antibody

  • 中文名稱：
    ZRANB3兔多克隆抗體
  • 貨號：
    CSB-PA705058LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA705058LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ZRANB3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZRANB3
  • 別名：
    4933425L19Rik antibody; AH2 antibody; Annealing helicase 2 antibody; DNA annealing helicase and endonuclease ZRANB3 antibody; MGC105033 antibody; MGC75012 antibody; OTTHUMP00000197449 antibody; Zinc finger Ran-binding domain-containing protein 3 antibody; Zinc finger; RAN- binding domain containing 3 antibody; ZRAB3_HUMAN antibody; Zranb3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DNA annealing helicase and endonuclease ZRANB3 protein (370-624AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ZRANB3 Antibody (CSB-PA705058LA01HU)，的標記方式是Non-conjugated。對于ZRANB3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA705058LB01HU ZRANB3 Antibody, HRP conjugated ELISA
    FITC CSB-PA705058LC01HU ZRANB3 Antibody, FITC conjugated
    Biotin CSB-PA705058LD01HU ZRANB3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.
  • 基因功能參考文獻：
    1. PCNA and ATP-dependency serve as a multi-layered regulatory mechanism that modulates ZRANB3 activity at replication forks. PMID: 28621305
    2. A large number of SNF2 family, DNA and ATP-dependent motor proteins are needed during transcription, DNA replication, and DNA repair to manipulate protein-DNA interactions and change DNA structure. SMARCAL1, ZRANB3, and HLTF are three related members of this family with specialized functions that maintain genome stability during DNA replication. [review] PMID: 28954549
    3. depletion of SMARCAL1, a SNF2-family DNA translocase that remodels stalled forks, restores replication fork stability and reduces the formation of replication stress-induced DNA breaks and chromosomal aberrations in BRCA1/2-deficient cells. In addition to SMARCAL1, other SNF2-family fork remodelers, including ZRANB3 and HLTF, cause nascent DNA degradation and genomic instability PMID: 29053959
    4. Damage-induced fork reversal in mammalian cells requires PCNA ubiquitination, UBC13, and K63-linked polyubiquitin chains, previously involved in error-free damage tolerance. Fork reversal in vivo also requires ZRANB3 translocase activity and its interaction with polyubiquitinated PCNA, pinpointing ZRANB3 as a key effector of error-free DNA damage tolerance. PMID: 28886337
    5. Here is described a substrate recognition domain within ZRANB3 that is needed for it to recognize forked DNA structures, hydrolyze ATP, catalyze fork remodeling, and act as a structure-specific endonuclease. PMID: 26884333
    6. ZRANB3 translocase, a SNF2 family member related to the SIOD disorder SMARCAL1 protein, is recruited by polyubiquitinated PCNA to promote fork restart following replication arrest. PMID: 22704558
    7. AH2 is recruited to stalled replication forks and that cells depleted of AH2 are hypersensitive to replication stresses. PMID: 22705370
    8. a role for ZRANB3 in the replication stress response and suggest new insights into how DNA repair is coordinated with DNA replication to maintain genome stability. PMID: 22759634
    9. structural and functional differences between AH2 and HARP suggest that different annealing helicases have distinct functions in the cell. PMID: 21078962

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 數據庫鏈接：

    HGNC: 25249

    OMIM: 615655

    KEGG: hsa:84083

    STRING: 9606.ENSP00000264159

    UniGene: Hs.658422



主站蜘蛛池模板： 亚洲精品午夜无码专区| 国产成年无码v片在线| 免费的黄网站在线观看| 国产人妻久久精品二区三区特黄 | 中文字幕无线码一区二区| 99久久99久久久精品齐齐综合色圆 | 久久久久国产精品人妻| 四虎国产精亚洲一区久久特色| 国产片av片永久免费观看| 精品国产一区二区三区久久久狼| 亚洲午夜福利在线观看| 性欧美疯狂xxxxbbbb| 精品国产福利一区二区| 97精品免费公开在线视频| 国内嫩模私拍精品视频| 老太脱裤让老头玩ⅹxxxx| 亚洲一区二区无码偷拍| 久久久久影院美女国产主播| 精品无码av无码免费专区| 国产成人无码专区| 欧美兽交xxxx×视频| 国产亚洲久久久久久久| 新国产三级视频在线播放| 国产二级一片内射视频播放| 久久精品高清一区二区三区| 夜夜高潮天天爽欧美| 精品人妻少妇一区二区三区不卡| 国内熟妇人妻色在线视频| 免费国产线观看免费观看| 久久久www成人免费无遮挡大片 | 欧洲av成本人在线观看免费| 狠狠色噜噜狠狠狠777米奇888| 国产精品欧美亚洲韩国日本久久| 成人亚洲精品久久久久| 99精品国产在热久久无毒| 色欲色香天天天综合vvv| 日本高清视频www夜色资源| 免费女上男下xx00xx00视频| 中字幕一区二区三区乱码| 起碰免费公开97在线视频| 亚洲乱码卡一卡二卡新区中国|