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  4. ZP2 Antibody

ZP2 Antibody

  • 中文名稱：
    ZP2兔多克隆抗體
  • 貨號：
    CSB-PA060121
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ZP2
  • 別名：
    OTTHUMP00000115849 antibody; Processed zona pellucida sperm-binding protein 2 antibody; Zona pellucida glycoprotein 2 antibody; zona pellucida glycoprotein ZP2 antibody; Zona pellucida protein A antibody; Zp-2 antibody; ZP2 antibody; ZP2_HUMAN antibody; ZPA antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ZP2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
  • 基因功能參考文獻：
    1. Mutations in ZP2 and ZP3 have dosage effects which can cause female infertility in humans. PMID: 28646452
    2. ZP2(51-149) sperm-binding domain is necessary for human gamete recognition and penetration through the zona pellucida. PMID: 24934154
    3. Studies indicate that eggs from mice lacking an ortholog of ZP2 do not contain a zona pellucida (ZP), and the mice are completely infertile due to a severely reduced number of ovulated eggs in their oviducts. PMID: 23417405
    4. observed sequence variations in exons of ZP2 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
    5. Of all zona pellucida (ZP) proteins, recombinant human ZPA demonstrates the highest binding activity toward acrosin PMID: 15950651
    6. Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns. PMID: 16407501
    7. ZP proteins were detected in both the oocyte and the granulosa cells as early as the primordial follicle stage in the human. The detection of ZP proteins in the quiescent primordial follicle suggests that these proteins have been present since oogenesis. PMID: 18033806

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  • 亞細胞定位：
    [Processed zona pellucida sperm-binding protein 2]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ZP domain family, ZPA subfamily
  • 組織特異性：
    Expressed in occytes(at protein level).
  • 數據庫鏈接：

    HGNC: 13188

    OMIM: 182888

    KEGG: hsa:7783

    STRING: 9606.ENSP00000219593

    UniGene: Hs.73982



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