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ZP1 Antibody

  • 中文名稱：
    ZP1兔多克隆抗體
  • 貨號：
    CSB-PA008280
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of LOVO cells using ZP1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ZP1
  • 別名：
    MGC87693 antibody; Processed zona pellucida sperm-binding protein 1 antibody; zona pellucida glycoprotein 1 (sperm receptor) antibody; Zona pellucida glycoprotein 1 antibody; zona pellucida protein 1 antibody; Zp 1 antibody; Zp-1 antibody; Zp1 antibody; ZP1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ZP1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
  • 基因功能參考文獻：
    1. this study identified a homozygous frameshift mutation in ZP1 in six family members with a form of infertility with an autosomal recessive mode of inheritance. PMID: 24670168
    2. observed sequence variations in exons of ZP1 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
    3. The 'ZP domain' module of human ZP1 has functional activity and may have a role during fertilization in humans. PMID: 20831819
    4. ZP1 binds to capacitated spermatozoa and induces acrosomal exocytosis. PMID: 20504872
    5. ZP proteins were detected in both the oocyte and the granulosa cells as early as the primordial follicle stage in the human. The detection of ZP proteins in the quiescent primordial follicle suggests that these proteins have been present since oogenesis. PMID: 18033806

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  • 相關疾病：
    Oocyte maturation defect 1 (OOMD1)
  • 亞細胞定位：
    [Processed zona pellucida sperm-binding protein 1]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ZP domain family, ZPB subfamily
  • 組織特異性：
    Expressed in oocytes (at protein level).
  • 數據庫鏈接：

    HGNC: 13187

    OMIM: 195000

    KEGG: hsa:22917

    STRING: 9606.ENSP00000278853

    UniGene: Hs.172130



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