在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ZNF703 Antibody, FITC conjugated

  • 中文名稱:
    ZNF703兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA026966LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ZNF703 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ZNF703
  • 別名:
    FLJ14299 antibody; ZEPPO1 antibody; Zinc finger elbow-related proline domain protein 1 antibody; Zinc finger protein 703 antibody; ZN703_HUMAN antibody; ZNF503L antibody; znf703 antibody; ZPO1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Zinc finger protein 703 protein (218-286AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
  • 基因功能參考文獻:
    1. ZNF703 can potently facilitate tumor growth and metastasis in many respects throughout the progression of CCA, which may act as an oncogene in CCA and can be considered as a novel potential therapeutic target. PMID: 27764785
    2. ZNF703 activated the PI3K/AKT/GSK-3beta signalling pathway and its downstream effectors, thus regulating the cell cycle and epithelial-mesenchymal transition. PMID: 29176314
    3. Results show that ZNF703 is up-regulated in 63.4% of non-small cell lung cancer (NSCLC) tumor samples and it may contribute to tumor development by activating the Akt/mTOR pathway in NSCLC. PMID: 27650486
    4. In vitro function assays demonstrated that SPRY4-IT1 cause promotion of cell viability in ESCC cells. Authors further verified that SPRY4-IT1 could also activate the expression of ZNF703 in ESCC cells, which might contribute to the role of SPRY4-IT1 in ESCC cells. PMID: 27453415
    5. Results show that ZNF703 overexpression is associated with adverse prognosis in head and neck squamous cell carcinomas, which might be a novel biomarker for this type of neoplasm. PMID: 26063961
    6. ZNF703 was a target of SPRY4-IT1. PMID: 25742952
    7. Results show that ZNF703 expression is upregulated in colorectal cancer tissues (CRC) and is significantly correlated with tumor size, pathological grading, and serosal and lymph node metastasis suggesting that it may act as an oncogene in CRC. PMID: 25017610
    8. The results showed that ZNF703 acts as a gastric cancer oncogene PMID: 24481460
    9. High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer. PMID: 24156016
    10. Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt/mTOR signaling pathway, downregulated ERalpha, and reduced the antitumor effect of tamoxifen. PMID: 23991038
    11. The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein. PMID: 22886885
    12. ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells. PMID: 21328542
    13. These data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer. PMID: 21337521
    14. Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53. PMID: 19330026

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation.
  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Elbow/Noc family
  • 組織特異性:
    Expressed in mammary epithelium.
  • 數據庫鏈接:

    HGNC: 25883

    KEGG: hsa:80139

    STRING: 9606.ENSP00000332325

    UniGene: Hs.288042



主站蜘蛛池模板: 色优久久久久综合网鬼色| 无人区码一码二码w358cc| 亚洲日韩精品欧美一区二区一| 午夜免费视频| 亚洲成av人片天堂网久久| 人妻丰满熟妇av无码区动漫| 国产日韩在线视看第一页| 国产精品兄妹在线观看麻豆| 国产99视频精品免视看9| 中国国产1级毛卡片| 亚洲人成色77777在线观看| 97超级碰碰人妻中文字幕| 国产第一页浮力影院入口| 日产精品中文一区二区三区| 成人影院yy111111在线观看| 亚洲午夜久久久久久久久电影网 | 性高湖久久久久久久久aaaaa| 中国熟妇浓毛hdsex| 天天躁日日躁狠狠躁人妻 | 国产中文字字幕乱码无限| 精品无码av无码专区| 免费全部高h视频无码| 在线精品亚洲第一区焦香| 国自产偷精品不卡在线| 欧美金妇欧美乱妇xxxx| 亚洲人成网线在线播放| 天天天天做夜夜夜做| 丰满人妻一区二区三区视频53| 情人伊人久久综合亚洲| 色播亚洲视频在线观看| 影音先锋日日狠狠久久| 欧美性猛交久久久乱大交小说| 99久久99久久久精品齐齐| 女人18毛片水真多| 国产成人午夜福利在线观看视频| 成人欧美一区二区三区视频| 免费看成人aa片无码视频羞羞网| 久久人人做人人妻人人玩精品hd | 亚洲人亚洲人成电影网站色| 亚洲人av高清无码| 国产精品人妻系列21p|