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  4. ZNF366 Antibody, HRP conjugated

ZNF366 Antibody, HRP conjugated

  • 中文名稱：
    ZNF366兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA026702LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ZNF366 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZNF366
  • 別名：
    ZNF366 antibody; Zinc finger protein 366 antibody; Dendritic cell-specific transcript protein antibody; DC-SCRIPT antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 366 protein (455-650AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.
  • 基因功能參考文獻：
    1. These data demonstrate that besides nuclear receptor regulation, DC-SCRIPT also modulates activation of NF-kappaBp65 after TLR activation in human DCs. PMID: 26170389
    2. these data show that DC-SCRIPT acts as a novel regulator of CDKN2B and induces cell cycle arrest in ESR1-positive breast cancer cells. PMID: 25663546
    3. DC-SCRIPT serves an important role in regulating GR function in DCs, corepressing GR-dependent upregulation of the tolerance-inducing transcription factor GILZ. PMID: 23440419
    4. DC-SCRIPT is a key regulator of androgen receptor and vitamin d receptor that play an opposite role in prostate cancer etiology and loss of DC-SCRIPT may be involved in the onset of prostate cancer. PMID: 22473304
    5. DC-SCRIPT has a primary role in the regulation of interleukin (IL)-10 production by monocytes. PMID: 22615205
    6. study provides a higher level of evidence that DC-SCRIPT is indeed an independent, pure prognostic, factor for primary breast cancer and shows that DC-SCRIPT mRNA expression is most informative for either ESR1-positive and/or ESR2-low pT1 tumors PMID: 21122099
    7. DC-SCRIPT can act as a tumor suppressor in breast cancer development.[review] PMID: 20478364
    8. DC-SCRIPT consists of a proline-rich region, 11 C2H2-type zinc fingers, and an acidic region. Localization studies reveal that DC-SCRIPT resides in the nucleus and that nuclear localization is critically dependent on the zinc fingers. (DC-SCRIPT) PMID: 16393996
    9. Results indicate that ZNF366 may play an important role in regulating the expression of genes in response to estrogen. PMID: 17085477
    10. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study PMID: 19525478

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in immature and mature dendritic cells (DCs). Not detected in other blood cell types.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18316

    OMIM: 610159

    KEGG: hsa:167465

    STRING: 9606.ENSP00000313158

    UniGene: Hs.224794



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