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  4. ZNF268 Antibody, HRP conjugated

ZNF268 Antibody, HRP conjugated

  • 中文名稱：
    ZNF268兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA026625LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ZNF268 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZNF268
  • 別名：
    ZNF268Zinc finger protein 268 antibody; Zinc finger protein HZF3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 268 protein (416-603AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
  • 基因功能參考文獻(xiàn)：
    1. The nuclear localization activity of KRAB domain is a conserved feature of ZNF268. PMID: 23665872
    2. These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB signaling. PMID: 23091055
    3. ZNF268 is a crucial downstream target and effector of GATA-1 PMID: 22235304
    4. This protein has a conserved KRAB domain which localizes to the nucleus and has transcriptional repressor activity. PMID: 12822888
    5. ZNF268 plays a role in early human liver development most likely by functioning through a cytoplasmic mechanism PMID: 15547661
    6. 4 alternative transcripts of ZNF268 were detected in the human blood cells. PMID: 16735226
    7. ZNF268 gene promoter is atypical and requires an intragenic element located within the first exon that mediates the effect of CREB for its activity PMID: 16787922
    8. ZNF268 gene may function as a transcriptional activator in the growth and differentiation of cells in development and/or pathogenesis. PMID: 16865230
    9. HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding PMID: 18375384
    10. results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex. PMID: 18677094
    11. Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 via its promoter. PMID: 18774934
    12. aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies. PMID: 18949428

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  • 亞細(xì)胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Nucleus. Cytoplasm.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13061

    OMIM: 604753

    KEGG: hsa:10795

    STRING: 9606.ENSP00000228289

    UniGene: Hs.124047



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