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  4. ZNF131 Antibody, HRP conjugated

ZNF131 Antibody, HRP conjugated

  • 中文名稱：
    ZNF131兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA026530LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ZNF131 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZNF131
  • 別名：
    ZNF131Zinc finger protein 131 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 131 protein (80-379AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role during development and organogenesis as well as in the function of the adult central nervous system. May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
  • 基因功能參考文獻：
    1. Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability. PMID: 28596487
    2. identify a novel substoichiometric interactor of the complex, transcription factor ZNF131, which recruits EMSY to a large number of active, H3K4me3 marked promoters. PMID: 26841866
    3. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131 PMID: 23404503
    4. these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor. PMID: 23159625
    5. SUMOylation is a novel regulator of ZNF131 action in estrogen signaling and breast cancer cell proliferation. PMID: 22467880
    6. The mechanism of Znf131 nuclear localization, is reported. PMID: 17306895
    7. Interaction between ZNF131 and ERalpha interrupts or prevents ERalpha binding to the estrogen response element. ZNF131 also suppresses the expression of TFF1. PMID: 18847501

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  • 亞細胞定位：
    Nucleus. Note=Sumoylation does not affect nuclear localization.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus.
  • 數據庫鏈接：

    HGNC: 12915

    OMIM: 604073

    KEGG: hsa:7690

    UniGene: Hs.535804



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