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ZMYND10 Antibody

  • 中文名稱:
    ZMYND10兔多克隆抗體
  • 貨號:
    CSB-PA026511GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ZMYND10
  • 別名:
    ZMYND10 antibody; BLU antibody; LUCA12.4 antibody; Zinc finger MYND domain-containing protein 10 antibody; Protein BLu antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ZMYND10
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
  • 基因功能參考文獻:
    1. BLU suppressed tumor formation by strengthening the antitumor immunity. PMID: 28029652
    2. A novel frameshift mutation (c.367delC) in ZMYND10, unique for Slavic primary ciliary dyskinesia population (PCD), was found in homozygous state in two unrelated PCD patients. PMID: 26824761
    3. Data identified a novel functional BLU promoter that was regulated by Sp1. Furthermore, the hypermethylated -39 CpG in BLU proximal promoter directly reduced its binding with Sp1. PMID: 26043875
    4. Data show that the zinc finger MYND-type containing 10 protein BLU gene may be one of the key components of signaling networks controlling tumor microenvironment and angiogenesis. PMID: 25347745
    5. Mutations in ZMYND10 cause primary ciliary dyskinesia. PMID: 23891471
    6. Methylation of BLU could be a potential prognostic biomarker for advanced ovarian serous carcinoma PMID: 23329649
    7. Data indicate that BLU could suppress the growth of ovarian carcinoma cells through down-regulation of Bcl-2 protein. PMID: 23628417
    8. these data indicated that methylation of the BLU promoter region is an early event during hepatocellular carcinoma development. PMID: 22766745
    9. The N-terminal of BLU was observed to interact with the C-terminal of SMEK1, a regulatory subunit of protein phosphatase 4. Furthermore, we determined the binding domains that are required for interaction between BLU and sMEK1. The N-terminal of BLU was observed to interact with the C-terminal of sMEK1. PMID: 22349239
    10. BLU may play a substantial role in the development and etiology of myelodysplastic syndrome. PMID: 22246278
    11. A significant correlation between BLU methylation and loss of expression of BLU was observed in gastric, colorectal and pancreatic cancers. PMID: 20394502
    12. These data suggest a significant role for epigenetic inactivation of BLU in the pathogenesis of common human cancers and that methylation inactivation of BLU occurs independent of RASSF1A in SCLC and neuroblastoma tumours. PMID: 12629521
    13. BLU may be one of the critical tumor suppressor genes on chromosome 3p21.3 involved in the development of nasopharyngeal carcinoma PMID: 12794757
    14. BLU, a candidate tumor suppressor gene, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. PMID: 15122337
    15. Smoking under age 18 is an independent risk for BLU hypermethylation, thus identifying a molecular alteration related to the epidemiologic effect of teenage smoking as a lung cancer risk. PMID: 15540210
    16. ninety-two percent of glioma tumor samples were methylated for RASSF1A, 30%-57% for BLU and 47% for MGMT, suggesting promoter methylation of these genes to be a common event in glioma tumorigenesis PMID: 18616639

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  • 相關疾病:
    Ciliary dyskinesia, primary, 22 (CILD22)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Apical cell membrane. Dynein axonemal particle.
  • 蛋白家族:
    ZMYND10 family
  • 數據庫鏈接:

    HGNC: 19412

    OMIM: 607070

    KEGG: hsa:51364

    STRING: 9606.ENSP00000231749

    UniGene: Hs.526735



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