在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ZMIZ1 Antibody, FITC conjugated

  • 中文名稱:
    ZMIZ1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA890749LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ZMIZ1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ZMIZ1
  • 別名:
    hZIMP10 antibody; KIAA1224 antibody; MIZ antibody; PIAS like protein hZimp10 antibody; PIAS like protein on chromosome 10 antibody; PIAS like protein Zimp10 antibody; PIAS-like protein Zimp10 antibody; RAI 17 antibody; Retinoic acid induced 17 antibody; Retinoic acid induced protein 17 antibody; Retinoic acid-induced protein 17 antibody; TRAFIP10 antibody; Zimp10 antibody; Zinc finger containing Miz1 PIAS like protein on chromosome 10 antibody; Zinc finger MIZ domain-containing protein 1 antibody; Zinc finger MIZ-type containing 1 antibody; Zmiz1 antibody; ZMIZ1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Zinc finger MIZ domain-containing protein 1 protein (405-559AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex.
  • 基因功能參考文獻:
    1. In a two-stage genome-wide association study and subsequent replication study to identify genetic factors associated with primary dysmenorrhoea in Chinese women, analysis provided evidence of a significant (P<5 x 10(-8)) association at rs76518691 in the gene ZMIZ1 and at rs7523831 near NGF. PMID: 28447608
    2. we have identified a molecular phenotype of MS defined by expression of the MS risk gene ZMIZ1 in blood, and by other genes, especially transcription factors. ZMIZ1 expression is affected by, and interacts with, the environmental risk factors EBV and Vitamin D. PMID: 28063629
    3. rs1250569 (ZMIZ1) and rs10114470 (TL1A) are two novel loci that indicate susceptibility to Inflammatory Bowel Disease in Han-Chinese patients. PMID: 28456797
    4. This case represents the first constitutional balanced translocation disrupting and fusing both MIZ-type containing and proline-rich 12 and provides clues for the potential function and effects of these in the central nervous system. PMID: 26163108
    5. At the ZMIZ1 locus, we show that perturbation of ZMIZ1 expression in human islets and beta-cells influences exocytosis and insulin secretion, highlighting a novel role for ZMIZ1 in the maintenance of glucose homeostasis. PMID: 26624892
    6. Targeting the NOTCH1-ZMIZ1 interaction might combat leukemic growth. PMID: 26522984
    7. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. PMID: 26403403
    8. ZMIZ1 is a susceptibility gene for vitiligo in Chinese population. PMID: 24667117
    9. ZMIZ1 is overexpressed in a significant percentage of human breast, ovarian, and colon cancers in addition to human squamous cell carcinomas, suggesting that ZMIZ1 may play a broader role in epithelial cancers. PMID: 23426136
    10. ZMIZ1 and activated NOTCH1 are coexpressed in a subset of human T-ALL patients and cell lines. PMID: 23161489
    11. First line of evidence demonstrates a physiological role for endogenous Zimp10 in regulating Smad3/4-mediated transcription. PMID: 16777850
    12. (RAI17) was found to be upregulated in WT-Add1 vs MUT-Add1 overexpressing cells, possibly representing a key molecule/axis for the functional Add1-induced effect PMID: 17512505
    13. Expression of exogenous hZimp10 enhances the transcriptional activity of p53 and knockdown of endogenous hZimp10 reduces the transcriptional activity of p53. PMID: 17584785
    14. provides evidence to demonstrate a crucial role for Zimp10 in vasculogenesis PMID: 17967885
    15. Fusion of ZMIZ1 to ABL1 is associated with a B-cell acute lymphoblastic leukemia with a t(9;10)(q34;q22.3) translocation PMID: 18007576

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleoplasm. Cytoplasm. Nucleus.
  • 組織特異性:
    Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 16493

    OMIM: 607159

    KEGG: hsa:57178

    STRING: 9606.ENSP00000334474

    UniGene: Hs.193118



主站蜘蛛池模板: 天天摸天天摸天天天天看| 国内精品伊人久久久久妇| 亚洲日韩欧美在线成人| 国产亚洲精品久久久久四川人| 爆乳熟妇一区二区三区| 亚洲乱码无人区卡1卡2卡3| 欧美日产欧美日产国产精品| 成视频年人黄网站免费视频| 国产乱人伦在线播放| 亚洲色在线v中文字幕| 99精品国产高清一区二区麻豆| 久久av无码精品人妻系列试探| 午夜成人理论福利片| 新版资源天堂中文| 久久久久国色av∨免费看| 亚洲国产成人久久综合| 午夜寂寞少妇aaa片毛片| 草草久久97超级碰碰碰| 国产美女精品视频线播放| 我把护士日出水了视频90分钟| 国产亚洲精品久久久ai换| 丰满的少妇xxxxx人| 免费国产在线精品一区二区三区| 麻豆网神马久久人鬼片| 国色天香天天影院综合网| 99热国产这里只有精品6| 国产疯狂伦交大片| 中文字幕亚洲乱码熟女在线| 久久综合少妇11p| 日本免费一区二区三区四区五区 | 女人被做到高潮免费视频| 国产高清精品软件丝瓜软件| 天堂…中文在线最新版在线 | 欧美 亚洲 国产 另类| 日本伦奷在线播放| 护士人妻hd中文字幕| 亚洲最大无码中文字幕| 成人片无码免费播放| 久久精晶国产99久久6| 国产亚洲日韩欧美另类第八页| 午夜伦4480yy私人影院|