在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ZIC3 Antibody

  • 中文名稱:
    ZIC3兔多克隆抗體
  • 貨號:
    CSB-PA026486ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA026486ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ZIC3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Heterotaxy 1 antibody; HTX antibody; HTX1 antibody; VACTERLX antibody; ZIC 3 antibody; Zic family member 3 (odd paired Drosophila homolog heterotaxy 1) antibody; Zic family member 3 antibody; Zic3 antibody; ZIC3_HUMAN antibody; Zinc finger protein 203 antibody; Zinc finger protein of the cerebellum 3 antibody; Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3) antibody; Zinc finger protein ZIC 3 antibody; ZNF203 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Zinc finger protein ZIC 3 protein (1-240AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
  • 基因功能參考文獻:
    1. current understanding of ZIC3 function and describe the potential role ZIC3 plays in important signalling pathways and their links to heterotaxy. PMID: 29442328
    2. Six novel pathogenic variants were identified in either male patients with heterotaxy or a female patient with multiple male deaths due to heterotaxy in the family. Truncating variants showed abnormal trafficking of mutated ZIC3 proteins. PMID: 27406248
    3. Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association PMID: 26294094
    4. detected the expression level of miR-564 and ZIC3 protein in tissue specimens, and found a significant negative correlation between them. Patients with low levels of miR-564 showed a poorer overall survival PMID: 26498524
    5. ZIC3 sequencing from unrelated patients with heterotaxy and congenital heart disease identified variants in 5.2% of sporadic male cases some of which were novel. Functional analyses show aberrant cytoplasmic localization. PMID: 24123890
    6. sumoylation targets human ZIC3 primarily on the consensus lysine residue K248, which is critical for the nuclear retention of ZIC3. PMID: 23872418
    7. Case Reports: situs inversus totalis and X-linked heterotaxy as a result of novel ZIC3 mutation. PMID: 22171628
    8. ZIC3 mutations are an important etiology in sporadic and familial heterotaxy. PMID: 23427188
    9. Mutations in Zinc Finger Protein of the Cerebellum 3 were identified in 4 of the 47 patients (8.5%) with heterotaxy syndrome. Our results expand the mutation spectrum of monogenic heterotaxy syndrome with associated cardiac anomalies. PMID: 21864452
    10. Data show that transcript, termed Zic3-B, encompasses exons 1, 2, and 4 whereas Zic3-A encompasses exons 1, 2, and 3. PMID: 21858219
    11. Disruption of Gli3-Zic3 interaction in the critical period for ventral body wall formation may contribute to omphalocele phenotype in Cd chick model. PMID: 21069353
    12. we have focused on the regulation of the Zic3 gene, which codes for a zinc finger transcription factor expressed in the organizer region at the beginning of gastrulation PMID: 12963115
    13. ZIC3 mutations in three classic heterotaxy kindreds and two sporadic congenital heart defect cases PMID: 14681828
    14. Results suggest that Zic3 plays a role in intra-retinal axon targeting, possibly through regulation of the expression of specific downstream genes involved in axon guidance. PMID: 14985256
    15. A positional effect caused by the balanced (X;21) translocation may be responsible for functional nullisomy of ZIC3 PMID: 15470371
    16. Nuclear import and export signals are essential for proper cellular trafficking and function of ZIC3. PMID: 17185387
    17. We studied a series of 42 cases of transposition of the great arteries; mutation in the X chromosome at the ZIC3 gene was found in two affected siblings (one male, one female) and their unaffected mother PMID: 17295247
    18. ZIC3 has a role in regulating cardiac gene expression PMID: 17468179
    19. in vitro interactions of ZIC3 with GLI3 and the effect of ZIC3 mutations identified in patients with either heterotaxy or isolated cardiovascular malformations. PMID: 17764085
    20. results indicate that ZIC3 is imported into the cell nucleus by the Karyopherin (Importin) system and that the impaired nuclear localization by the ZF1 mutation is not due to a direct influence on the nuclear localization signal PMID: 18716025

    顯示更多

    收起更多

  • 相關疾病:
    Heterotaxy, visceral, 1, X-linked (HTX1); VACTERL association X-linked with or without hydrocephalus (VACTERLX); Congenital heart defects, multiple types, 1, X-linked (CHTD1)
  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    GLI C2H2-type zinc-finger protein family
  • 數據庫鏈接:

    HGNC: 12874

    OMIM: 300265

    KEGG: hsa:7547

    STRING: 9606.ENSP00000287538

    UniGene: Hs.111227



主站蜘蛛池模板: 国产男女猛烈视频在线观看| 都市激情 在线 亚洲 国产| 色欲av巨乳无码一区二区| 中文字幕亂倫免賛視頻| 爱情岛论坛网亚洲品质| 唐人社导航福利精品| 一二三四视频社区在线| 提莫影院av毛片入口| 久久精品视频在线看| 国产剧情av麻豆香蕉精品| 亚洲一卡2卡三卡四卡精品| 中文字幕日韩人妻不卡一区| 黑人巨大精品欧美一区二区免费 | 亚洲国产中文在线二区三区免| 在线观看的网站| 2020国产亚洲美女精品久久久| 老子影院无码午夜伦不卡| 成人午夜高潮免费视频| 国产午夜大地久久| 亚洲精品卡一卡三卡四卡乱码| 国产一区二区三区高清在线观看| 色婷婷av久久久久久久| 午夜成人爽爽爽视频在线观看| 精品无码乱码av| 国产精品免费看久久久| 午夜精品久久久内射近拍高清| 青乐娱精品视频一国产分类| 国产99视频精品免视看7| 国产亚洲精品aaaa片app| 99久久精品国产成人综合| 丝袜高潮流白浆潮喷在线播放| 久久婷婷国产综合精品| 日日噜噜夜夜狠狠久久丁香五月| 久久久一本精品99久久精品66直播| 欧美情侣性视频| 日韩人妻熟女中文字幕a美景之屋| 在线毛片片免费观看| 久久婷婷五月综合国产尤物app| 老太脱裤让老头玩ⅹxxxx| 精品麻豆一区二区三区乱码| 无码人妻久久一区二区三区app |