在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ZIC3 Antibody

  • 中文名稱:
    ZIC3兔多克隆抗體
  • 貨號:
    CSB-PA026486ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA026486ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ZIC3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Heterotaxy 1 antibody; HTX antibody; HTX1 antibody; VACTERLX antibody; ZIC 3 antibody; Zic family member 3 (odd paired Drosophila homolog heterotaxy 1) antibody; Zic family member 3 antibody; Zic3 antibody; ZIC3_HUMAN antibody; Zinc finger protein 203 antibody; Zinc finger protein of the cerebellum 3 antibody; Zinc finger protein ZIC 3 (Zinc finger protein of the cerebellum 3) antibody; Zinc finger protein ZIC 3 antibody; ZNF203 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Zinc finger protein ZIC 3 protein (1-240AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
  • 基因功能參考文獻:
    1. current understanding of ZIC3 function and describe the potential role ZIC3 plays in important signalling pathways and their links to heterotaxy. PMID: 29442328
    2. Six novel pathogenic variants were identified in either male patients with heterotaxy or a female patient with multiple male deaths due to heterotaxy in the family. Truncating variants showed abnormal trafficking of mutated ZIC3 proteins. PMID: 27406248
    3. Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association PMID: 26294094
    4. detected the expression level of miR-564 and ZIC3 protein in tissue specimens, and found a significant negative correlation between them. Patients with low levels of miR-564 showed a poorer overall survival PMID: 26498524
    5. ZIC3 sequencing from unrelated patients with heterotaxy and congenital heart disease identified variants in 5.2% of sporadic male cases some of which were novel. Functional analyses show aberrant cytoplasmic localization. PMID: 24123890
    6. sumoylation targets human ZIC3 primarily on the consensus lysine residue K248, which is critical for the nuclear retention of ZIC3. PMID: 23872418
    7. Case Reports: situs inversus totalis and X-linked heterotaxy as a result of novel ZIC3 mutation. PMID: 22171628
    8. ZIC3 mutations are an important etiology in sporadic and familial heterotaxy. PMID: 23427188
    9. Mutations in Zinc Finger Protein of the Cerebellum 3 were identified in 4 of the 47 patients (8.5%) with heterotaxy syndrome. Our results expand the mutation spectrum of monogenic heterotaxy syndrome with associated cardiac anomalies. PMID: 21864452
    10. Data show that transcript, termed Zic3-B, encompasses exons 1, 2, and 4 whereas Zic3-A encompasses exons 1, 2, and 3. PMID: 21858219
    11. Disruption of Gli3-Zic3 interaction in the critical period for ventral body wall formation may contribute to omphalocele phenotype in Cd chick model. PMID: 21069353
    12. we have focused on the regulation of the Zic3 gene, which codes for a zinc finger transcription factor expressed in the organizer region at the beginning of gastrulation PMID: 12963115
    13. ZIC3 mutations in three classic heterotaxy kindreds and two sporadic congenital heart defect cases PMID: 14681828
    14. Results suggest that Zic3 plays a role in intra-retinal axon targeting, possibly through regulation of the expression of specific downstream genes involved in axon guidance. PMID: 14985256
    15. A positional effect caused by the balanced (X;21) translocation may be responsible for functional nullisomy of ZIC3 PMID: 15470371
    16. Nuclear import and export signals are essential for proper cellular trafficking and function of ZIC3. PMID: 17185387
    17. We studied a series of 42 cases of transposition of the great arteries; mutation in the X chromosome at the ZIC3 gene was found in two affected siblings (one male, one female) and their unaffected mother PMID: 17295247
    18. ZIC3 has a role in regulating cardiac gene expression PMID: 17468179
    19. in vitro interactions of ZIC3 with GLI3 and the effect of ZIC3 mutations identified in patients with either heterotaxy or isolated cardiovascular malformations. PMID: 17764085
    20. results indicate that ZIC3 is imported into the cell nucleus by the Karyopherin (Importin) system and that the impaired nuclear localization by the ZF1 mutation is not due to a direct influence on the nuclear localization signal PMID: 18716025

    顯示更多

    收起更多

  • 相關疾病:
    Heterotaxy, visceral, 1, X-linked (HTX1); VACTERL association X-linked with or without hydrocephalus (VACTERLX); Congenital heart defects, multiple types, 1, X-linked (CHTD1)
  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    GLI C2H2-type zinc-finger protein family
  • 數據庫鏈接:

    HGNC: 12874

    OMIM: 300265

    KEGG: hsa:7547

    STRING: 9606.ENSP00000287538

    UniGene: Hs.111227



主站蜘蛛池模板: 久久久久久久99精品免费观看| 欧美亚洲偷图色综合| 亚洲精品无码av中文字幕电影网站 | 潮喷无码正在播放| 国产精品成人午夜久久| 国产成人久久精品二区三区| 波多野结衣50连登视频| 猫咪www免费人成网站无码| 成人a片产无码免费视频在线观看| 国产精品人妻久久久久| 亚洲综合无码一区二区| 欧美一性一乱一交一视频| 国产杨幂丝袜av在线播放| 国产萌白酱喷水视频在线观看 | 国产精品无码翘臀在线看| 蜜桃视频一区二区三区在线观看| 爱性久久久久久久久| 香蕉噜噜噜噜私人影院| 欧美成人无码a区视频在线观看| 黄a大片av永久免费| 欧美黑人欧美精品刺激| 护士张开腿被奷日出白浆| 中文无码日韩欧免费视频| 精品无码国产av一区二区| 国产高清视频一区三区| 成人毛片av免费| 麻花传媒mv国产免费观看视频 | 深夜国产成人福利在线观看| 五月综合激情婷婷六月色窝| 欧美牲交a欧牲交aⅴ久久| 青草视频在线观看视频| 97色成人综合网站| 少妇被躁爽到高潮无码文| 色妞色视频一区二区三区四区| 色欲视频综合免费天天| 午夜福利日本一区二区无码| 欧美老熟妇videos极品另类| 久久日本三级韩国三级| 18禁超污无遮挡无码网址| 久久久久99精品成人片试看| 色综合欧美在线视频区|