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  4. ZFYVE16 Antibody

ZFYVE16 Antibody

  • 中文名稱：
    ZFYVE16兔多克隆抗體
  • 貨號：
    CSB-PA800100ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA800100ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA800100ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA800100ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ZFYVE16 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AI035632 antibody; B130024H06Rik antibody; B130031L15 antibody; DKFZp686E13162 antibody; Endofin antibody; Endosomal associated FYVE domain protein antibody; Endosome associated FYVE domain protein antibody; Endosome-associated FYVE domain protein antibody; KIAA0305 antibody; KIAA0305; antibody; mKIAA0305 antibody; OTTMUSP00000029589 antibody; RGD1564784 antibody; ZFY16_HUMAN antibody; ZFYVE16 antibody; Zinc finger FYVE domain containing protein 16 antibody; Zinc finger FYVE domain-containing protein 16 antibody; Zinc finger; FYVE domain containing 16 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger FYVE domain-containing protein 16 protein (1-280AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.
  • 基因功能參考文獻：
    1. Two SNPs located near the ZFYVE16 gene on chromosome 5 may have played a role in the early, multicompartment sacrocolpopexy failure. PMID: 26944198
    2. Disruption of proper localization to the endosomes and the Y515 phosphorylation of Endofin enhanced MAPK activation suggesting that Endofin negatively modulates EGFR signaling following receptor endocytosis. PMID: 19887107
    3. marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment PMID: 14613930
    4. The key mode of action of Trx-SARA was to reduce the level of Smad2 and Smad3 in complex with Smad4 after TGF-beta1 stimulation. PMID: 16775010
    5. Facilitates TGF-beta signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing Smad4 to the proximity of the receptor complex. PMID: 17272273
    6. our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID: 17570516

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  • 亞細胞定位：
    Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).
  • 組織特異性：
    Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.
  • 數據庫鏈接：

    HGNC: 20756

    OMIM: 608880

    KEGG: hsa:9765

    STRING: 9606.ENSP00000337159

    UniGene: Hs.482660



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