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  4. ZFP42 Antibody, Biotin conjugated

ZFP42 Antibody, Biotin conjugated

  • 中文名稱：
    ZFP42兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA856985LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ZFP42 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZFP42
  • 別名：
    hREX-1 antibody; Reduced Expression 1 Protein antibody; Reduced expression protein 1 antibody; Rex-1 antibody; REX1 antibody; REX1 transcription factor antibody; Zfp-42 antibody; Zfp42 antibody; ZFP42 zinc finger protein antibody; ZFP42_HUMAN antibody; Zinc finger protein 42 homolog antibody; Zinc finger protein 754 antibody; ZNF754 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 42 homolog protein (6-68AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal.
  • 基因功能參考文獻：
    1. Results provide evidence that bFGF regulates stemness maintenance in stem cells isolated from human exfoliated deciduous teeth (SHEDs) by enhancing REX-1 mRNA expression via the FGFR and Akt signaling pathways. Moreover, IL-6 is also involved in the bFGF-induced REX1 expression. PMID: 27883224
    2. Results show that a novel pluripotency regulator, REX1, is essential for pluripotency and reprogramming. PMID: 23939908
    3. reduced expression protein-1 (REX-1) is widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination. PMID: 21446939
    4. hRex1 binds to the hRex1 promoter region at -298 bp and positively regulates hRex1 transcription, but this regulation is lost in PC-3 human prostate cancer cells. PMID: 20232320
    5. REX1 functions in normal adult epithelial cells and tumorigenic stem cells. PMID: 16865673
    6. Data show that Oct-4, Rex-1, and Gata-4 expression in human mesenchymal stem cells increases cell differentiation efficiency but not hTERT expression. PMID: 17211834
    7. expression of REX-1 in meiotic cells from both testes and ovary indicate a role in meiosis. PMID: 18281244
    8. MAPCs express the OCT4 and REX1 transcription factors, two specific markers of undifferentiated embryonic stem (ES) cells. PMID: 15790780

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem ce
  • 數據庫鏈接：

    HGNC: 30949

    OMIM: 614572

    KEGG: hsa:132625

    STRING: 9606.ENSP00000317686

    UniGene: Hs.335787



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