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  4. ZDHHC20 Antibody

ZDHHC20 Antibody

  • 中文名稱：
    ZDHHC20兔多克隆抗體
  • 貨號：
    CSB-PA722800LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescent analysis of A549 cells using CSB-PA722800LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ZDHHC20 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZDHHC20
  • 別名：
    ZDHHC20; Palmitoyltransferase ZDHHC20; Acyltransferase ZDHHC20; DHHC domain-containing cysteine-rich protein 20; DHHC20; Zinc finger DHHC domain-containing protein 20
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Probable palmitoyltransferase ZDHHC20 protein (75-130AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ZDHHC20 Antibody (CSB-PA722800LA01HU)，的標記方式是Non-conjugated。對于ZDHHC20 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA722800LB01HU ZDHHC20 Antibody, HRP conjugated ELISA
    FITC CSB-PA722800LC01HU ZDHHC20 Antibody, FITC conjugated
    Biotin CSB-PA722800LD01HU ZDHHC20 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains.
  • 基因功能參考文獻：
    1. crystal structure determined; active site resides at the membrane-cytosol interface; acyl chain binds in a cavity formed by the transmembrane domain; propose a mechanism for acyl chain-length selectivity in DHHC enzymes on the basis of cavity mutants with preferences for shorter and longer acyl chains PMID: 29326245
    2. Targeting of a peripheral modulator of EGFR signaling, DHHC20, causes a loss of signal regulation and susceptibility to EGFR inhibitor-induced cell death. PMID: 27153536
    3. DHHC20 is a human N-terminal-myristoyl-directed palmitoyl acyltransferase involved in cellular transformation, that may play a role in cancer. PMID: 20334580
  • 亞細胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
  • 蛋白家族：
    DHHC palmitoyltransferase family
  • 數據庫鏈接：

    HGNC: 20749

    KEGG: hsa:253832

    STRING: 9606.ENSP00000371905

    UniGene: Hs.564611



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