在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ZDHHC2 Antibody, Biotin conjugated

  • 中文名稱:
    ZDHHC2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA883437LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ZDHHC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ZDHHC2; REAM; REC; ZNF372; Palmitoyltransferase ZDHHC2; Acyltransferase ZDHHC2; Reduced expression associated with metastasis protein; Ream; Reduced expression in cancer protein; Rec; Zinc finger DHHC domain-containing protein 2; DHHC-2; Zinc finger protein 372
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Palmitoyltransferase ZDHHC2 protein (230-367AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses. In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors. Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons. Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane.; (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation.
  • 基因功能參考文獻:
    1. These results suggest an important role for ZDHHC2 as a tumor suppressor in metastasis and recurrence of HCC. PMID: 24995331
    2. reduced ZDHHC2 expression is associated with lymph node metastasis and independently predicts an unfavorable prognosis in gastric adenocarcinoma patients PMID: 23457560
    3. DHHC2 localizes primarily to the endoplasmic reticulum and Golgi apparatus suggesting that it is involved in S-acylation of newly-synthesized or recycling Lck involved in T cell signalling. PMID: 22034844
    4. The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain PMID: 21471008
    5. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. PMID: 21343290
    6. DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151 PMID: 18508921

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, synapse, postsynaptic density. Postsynaptic recycling endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族:
    DHHC palmitoyltransferase family
  • 組織特異性:
    Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.
  • 數據庫鏈接:

    HGNC: 18469

    KEGG: hsa:51201

    STRING: 9606.ENSP00000262096

    UniGene: Hs.728241



主站蜘蛛池模板: 免费无码又爽又刺激网站| 男女做爰猛烈啪啪吃奶动| 午夜国产亚洲精品一区| 男女18禁啪啪无遮挡| 国产麻豆md传媒视频| 大香伊蕉在人线国产网站首页 | 精品视频一区二区三三区四区| 麻豆ā片免费观看在线看| 女人国产香蕉久久精品| 9色国产深夜内射| 韩国精品一区二区三区四区| 九九热爱视频精品| 国产又色又刺激高潮视频| 国产福利视频在线观看| 国产在线精品一区二区| 午夜视频在线在免费| 男女啪啪网站大全免费| 胸大美女又黄的网站| 中文无码精品a∨在线观看不卡| 国产精品欧美成人片| 蜜桃av麻豆av果冻传媒| 少妇熟女高潮流白浆| 国产男生午夜福利免费网站| 97se亚洲精品一区二区 | 亚洲精品无码久久久| 狠狠精品干练久久久无码中文字幕| 午夜福利精品亚洲不卡| 老熟妇hd小伙子另类| 乱子伦视频在线看| 人妻aⅴ中文字幕| 国产精品亚洲专区无码老司国| 精产国品一二三产品蜜桃| 国产精品视频免费播放| 青青草国产精品免费观看| 99久久国产综合精品五月天| 色橹橹欧美在线观看视频高清 | 2020精品自拍视频曝光| 在线观看片免费人成视频无码| 亚洲精品成人区在线观看| 久久精品人妻一区二区三区 | av天堂午夜精品蜜臀av|