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  4. ZBTB18 Antibody, Biotin conjugated

ZBTB18 Antibody, Biotin conjugated

  • 中文名稱：
    ZBTB18兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA026604LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ZBTB18 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZBTB18
  • 別名：
    C2H2171 antibody; 58 kDa repressor protein antibody; C2H2 171 antibody; RP58 antibody; TAZ 1 antibody; TAZ-1 antibody; TAZ1 antibody; Transcriptional repressor RP58 antibody; Translin associated zinc finger protein 1 antibody; Translin-associated zinc finger protein 1 antibody; ZBTB18 antibody; Zinc finger and BTB domain containing protein 18 antibody; Zinc finger and BTB domain-containing protein 18 antibody; Zinc finger protein 238 antibody; Zinc finger protein C2H2 171 antibody; Zinc finger protein C2H2-171 antibody; ZN238_HUMAN antibody; ZNF238 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger and BTB domain-containing protein 18 protein (62-364AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.
  • 基因功能參考文獻(xiàn)：
    1. This study characterizes the role of the putative tumor suppressor ZBTB18 and its regulation by promoter hypermethylation, which appears to be a common mechanism to silence ZBTB18 in the mesenchymal subtype of GBM and provides a new mechanistic opportunity to specifically target this tumor subclass PMID: 28512252
    2. results confirm and refine the complex genotype-phenotype correlations existing in the 1qter microdeletion syndrome and define more precisely the neurodevelopmental phenotypes associated with genetic alterations of AKT3, ZBTB18 and HNRNPU in humans PMID: 28283832
    3. De novo missense and truncating variants in ZBTB18 cause intellectual disability. PMID: 27598823
    4. This report indicates that haploinsufficiency of additional genes beside ZBTB18 causes the high frequency of corpus callosum anomalies in patients with microdeletions of 1q43q44 and underlines the importance of an NGS-based molecular diagnostic in complex phenotypes PMID: 28345786
    5. repression of the CR2/CD21 promoter can occur through one of the E-box motifs via recruitment of RP58. PMID: 25817480
    6. RP58 may act to favor neuronal differentiation and brain growth by coherently repressing multiple proneurogenic genes in a timely manner. PMID: 22095278
    7. Findings indicate that ZNF238 is a novel brain tumor suppressor and its reactivation in tumors could open a novel anticancer strategy. PMID: 20103640

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  • 相關(guān)疾病：
    Mental retardation, autosomal dominant 22 (MRD22)
  • 亞細(xì)胞定位：
    Nucleus. Note=Associates with condensed chromatin.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily
  • 組織特異性：
    Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13030

    OMIM: 608433

    KEGG: hsa:10472

    STRING: 9606.ENSP00000351539

    UniGene: Hs.69997



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