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  4. ZAR1 Antibody

ZAR1 Antibody

  • 中文名稱：
    ZAR1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA004554
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using ZAR1 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ZAR1
  • 別名：
    Oocyte-specific maternal effect factor antibody; zar1 antibody; ZAR1_HUMAN antibody; zygote arrest 1 antibody; Zygote arrest protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ZAR1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Essential for female fertility. May play a role in the oocyte-to-embryo transition.
  • 基因功能參考文獻(xiàn)：
    1. ZAR1 has oncogenic effects in neuroblastoma by suppressing cell differentiation via regulation of MYCN expression.Elevated ZAR1 expression level is closely related to poor prognosis of patients with neuroblastoma. PMID: 28791558
    2. Study shows for the first time the lung tumor-specific epigenetic inactivation of ZAR1 due to DNA methylation of its CpG island promoter. Furthermore, ZAR1 was characterized by the ability to block tumor growth through the inhibition of cell cycle progression in cancer cell lines. PMID: 28588743
    3. A decreased methylation level at CpG sites of ZAR1 exon 1/intron 1. CpGi could serve as a biomarker for invasive bladder cancer. PMID: 25227574
    4. ZAR1 and SFRP4 qMSP could be used as potential biomarker for CC diagnosis PMID: 24787227
    5. Hypermethylation of ZAR1 regions is extremely frequent in neuroblastomas and correlates with established markers of progressive disease and outcome. PMID: 23583134
    6. Findings indicate that non-promoter hypermethylation of ZAR1 is extremely frequent in diffuse gliomas and pituitary adenomas, but methylation-related aberrant ZAR1 expression is far less likely to be related to glioma tumorigenesis. PMID: 21206179
    7. we identified a frequently aberrant methylated region within the Zygote arrest 1 (ZAR1) gene in melanoma and demonstrated a distinct methylation pattern between melanoma and nevus.The involvement of ZAR1 in the carcinogenesis of melanoma remains unclear. PMID: 20654783
    8. The carboxyl-termini of these ZAR1 proteins contain an important functional domain that is conserved through vertebrate evolution and that may be necessary for normal female reproduction in the transition from oocyte to embryonic life. PMID: 12773403
    9. Zygote arrest 1 (ZAR1) could be implicated in regulation of meiosis and post meiotic differentiation of male and female germ cells through expression of shorter splicing variants. Central role of this gene in early reproductive processes. PMID: 16551357

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    ZAR1 family
  • 組織特異性：
    Ovary and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20436

    OMIM: 607520

    KEGG: hsa:326340

    STRING: 9606.ENSP00000329803

    UniGene: Hs.276457



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