在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ZAK Antibody

  • 中文名稱:
    ZAK兔多克隆抗體
  • 貨號(hào):
    CSB-PA030032
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AZK antibody; Cervical cancer suppressor gene 4 protein antibody; HCCS 4 antibody; HCCS-4 antibody; HCCS4 antibody; Human cervical cancer suppressor gene 4 protein antibody; Leucine zipper and sterile alpha motif containing kinase antibody; Leucine zipper- and sterile alpha motif-containing kinase antibody; Mitogen activated protein kinase kinase kinase MLT antibody; Mitogen-activated protein kinase kinase kinase MLT antibody; Mixed lineage kinase 7 antibody; Mixed lineage kinase related kinase antibody; Mixed lineage kinase related kinase MRK beta antibody; Mixed lineage kinase with a leucine zipper and a sterile alpha motif antibody; Mixed lineage kinase-related kinase antibody; MLK 7 antibody; MLK like mitogen activated protein triple kinase antibody; MLK related kinase antibody; MLK-like mitogen-activated protein triple kinase antibody; MLK-related kinase antibody; MLK7 antibody; Mlklak antibody; MLT antibody; MLTK_HUMAN antibody; MRK antibody; Sterile alpha motif and leucine zipper containing kinase AZK antibody; Sterile alpha motif- and leucine zipper-containing kinase AZK antibody; Zak antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from Human MLTK around the non-phosphorylation site of S165.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Involved in limb development.; Phosphorylates histone H3 at 'Ser-28'. May have role in neoplastic cell transformation and cancer development. Causes cell shrinkage and disruption of actin stress fibers.
  • 基因功能參考文獻(xiàn):
    1. The ZAK rs3769201 and rs722864 may be functional susceptibility loci for lung cancer risk. PMID: 29071797
    2. The expression of ZAKbeta is dependent on ZAKalpha expression, and ZAKbeta further enhances ZAKalpha expression and results in synergistic enhancement of apoptosis in osteosarcoma cells. PMID: 29654619
    3. Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers. PMID: 26522728
    4. Recessive mutations in the kinase ZAK - novel cause of congenital myopathy. PMID: 27816943
    5. ZAK is a key player in mammalian limb patterning in humans and mice. PMID: 26755636
    6. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers. PMID: 24807215
    7. The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway. PMID: 25013376
    8. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK) PMID: 24170769
    9. MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38 PMID: 23319595
    10. The genes identified KTN1, ROCK1, and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone PMID: 21305317
    11. decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP-1 transcription factor. PMID: 20331627
    12. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1, and show that MRK-beta could also activate MSK1 through direct interaction. PMID: 20408143
    13. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression. PMID: 12535642
    14. Data show that in response to radiation, MRK controls two independent pathways: the Chk2-Cdc25A pathway leading to cell cycle arrest and the p38gamma MAPK pathway PMID: 15342622
    15. Results suggest that a ZAK mediates TGF-beta-induced cardiac hypertrophic growth via a novel TGF-beta signaling pathway. PMID: 15465036
    16. ZAK induces characteristic hypertrophic growth features, including increased cell size, elevated atrial natriuretic factor expression, and increased actin fiber organization PMID: 15485649
    17. Mixed lineage kinase 7 (MLK7), a splice variant of the ZAK gene, encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation. PMID: 15737997
    18. data demonstrate that a ZAK isoform(s) is the MAP3Kinase that transduces the ribotoxic stress response PMID: 18331592

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Split-foot malformation with mesoaxial polydactyly (SFMMP)
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 組織特異性:
    Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17797

    OMIM: 609479

    KEGG: hsa:51776

    STRING: 9606.ENSP00000364361

    UniGene: Hs.444451



主站蜘蛛池模板: 国产日韩在线视看高清视频手机 | 午夜三级a三级三点| 激情综合婷婷丁香五月蜜桃| 国产极品粉嫩福利姬萌白酱| 久久久久噜噜噜亚洲熟女综合 | 无码孕妇孕交在线观看| 精品一区二区三区免费播放| 麻豆传煤入口免费进入2023| 日产精品99久久久久久| 无码av免费网站| 99这里只有精品| 色综合天天综合高清网国产在线| 亚洲精品aa片在线观看国产| 久久偷看各类wc女厕嘘嘘偷窃 | 高清中文字幕在线a片| 国产99视频精品免费视看9| 日本一上一下爱爱免费| 中文字幕精品一区二区2021年| av怡红院一区二区三区| 九九久久精品免费观看| 在线播放偷拍一区精品| 欧美老妇交乱视频在线观看| 24小时日本在线www免费的 | 亚洲乱码中文字幕手机在线| 男女做爰猛烈叫床视频免费| 久久久国产成人一区二区| 亚洲 欧美 影音先锋| 北条麻妃在线一区二区| 日韩av高清在线观看| 中文字幕乱码亚洲无线码三区| 国产区精品福利在线社区| 国产精品福利自产拍久久| 亚洲国产精品成人天堂| 国产沙发午睡系列999| 玩弄放荡人妻少妇系列| 久9视频这里只有精品| 国产欧美二区综合| 国产一本一道久久香蕉| 日本少妇高潮喷水xxxxxxx| 国模小婕私拍鲜嫩玉门| 伊人狼人大焦香久久网|