在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

YTHDF3 Antibody, HRP conjugated

  • 中文名稱:
    YTHDF3兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA800225LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) YTHDF3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    YTHDF3
  • 別名:
    FLJ31657 antibody; YTH domain family 3 antibody; YTH domain family member 3 antibody; YTH domain family protein 3 antibody; YTH domain-containing family protein 3 antibody; YTHD3_HUMAN antibody; YTHDF 3 antibody; YTHDF3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human YTH domain-containing family protein 3 protein (315-585AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs. Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification. Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation. Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation.; Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection. May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome.
  • 基因功能參考文獻:
    1. These results indicate that together with YTHDF1 and YTHDF2, YTHDF3 plays critical roles to accelerate metabolism of N(6)-methyladenosine -modified mRNAs in the cytoplasm. PMID: 28106072
    2. The authors found that the overexpression of YTHDF proteins in cells inhibited HIV-1 infection mainly by decreasing HIV-1 reverse transcription, while knockdown of YTHDF1-3 in cells had the opposite effects. Moreover, silencing the N(6)-methyladenosine writers decreased HIV-1 Gag protein expression in virus-producing cells, while silencing the N(6)-methyladenosine erasers increased Gag expression. PMID: 27371828
    3. Includes a multi-species analysis of YTHDF family members. PMID: 20463905
  • 亞細胞定位:
    Cytoplasm, cytosol. Cytoplasm, P-body. Cytoplasm, Stress granule.
  • 數據庫鏈接:

    HGNC: 26465

    KEGG: hsa:253943

    UniGene: Hs.491861



主站蜘蛛池模板: 苍井空张开腿实干12次| 人妻无码av中文系列久| 国产真实老熟女无套内射| 国产乱码精品一区二区三区中文| 久久青青草原国产免费播放| 女性自慰网站免费观看w | 亚洲综合狠狠丁香五月| 综合欧美日韩国产成人| 爆乳2把你榨干哦ova在线观看 | 国产精品白浆无码流出视频| 最新精品香蕉在线| 在线人人车操人人看视频| 变态另类牲交乱| 亚洲精品乱码久久久久久按摩| 成熟老妇女视频| 国产精品国产三级欧美二区| 成人无遮挡18禁免费视频| 米奇影院888奇米色99在线| 日本精品高清一区二区| 国产午夜无码精品免费看| 国产99久9在线视频 | 传媒| 天天躁夜夜躁狠狠综合2020| 丰满熟妇乱又伦| 成人午夜国产内射主播| 中文字幕乱码久久午夜不卡| 99热精国产这里只有精品| 色综合中文综合网| 亚洲精品福利一区二区三区蜜桃| 日本三级欧美三级人妇视频| 永久黄网站色视频免费直播 | 日本一区二区三区免费更新不卡| 少妇被又大又粗下爽a片| 69综合精品国产二区无码| 精品人妻大屁股白浆无码| 久久亚洲国产精品123区| 人成午夜免费视频无码| 99re6在线视频精品免费下载| 97人洗澡人人澡人人爽人人模| 久久精品中文字幕第一页| 国语自产少妇精品视频| 精品噜噜噜噜久久久久久久久|