在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. YOD1 Antibody

YOD1 Antibody

  • 中文名稱：
    YOD1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA003607
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using OTUD2 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    DUBA-8 antibody; DUBA8 antibody; HIN-7 antibody; HIV-1-induced protease 7 antibody; HsHIN7 antibody; OTU domain containing 2 antibody; OTU domain-containing protein 2 antibody; OTU1_HUMAN antibody; OTUD2 antibody; PRO0907 antibody; RP11-164O23.1 antibody; Ubiquitin thioesterase OTU1 antibody; yod1 antibody; YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) antibody; YOD1 OTU deubiquinating enzyme 1 homolog (yeast) antibody; YOD1 OTU deubiquinating enzyme 1; S. cerevisiae; homolog of antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human OTUD2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation.
  • 基因功能參考文獻(xiàn)：
    1. This study showed that YOD1 overexpression enhances cell migration by promoting TGF-beta3 signaling which may play an important role in lip and palate formation. PMID: 30145984
    2. Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS, and enhances the stability of ITCH, which leads to reduced levels of LATS and a subsequent increase in the YAP/TAZ level. PMID: 28416659
    3. Data suggest that YOD1 is a novel regulator of the Hippo pathway, and thereby a potential therapeutic target for liver cancer. PMID: 28502290
    4. These data define that YOD1 antagonizes TRAF6/p62-dependent IL-1 signaling to NF-kappaB. PMID: 28244869
    5. Upon damage, p97 translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response. PMID: 27753622
    6. activity of the p97-associated deubiquitinylase YOD1 is also required for substrate disposal PMID: 26463207
    7. miR-373 increases proliferation by directly targeting YOD1 in cervical cancer. PMID: 25747718
    8. The assignment of a p97-associated ubiquitin processing function to YOD1 adds to our understanding of p97's role in the dislocation of misfolded proteins from the endoplasmic reticulum. PMID: 19818707

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25035

    OMIM: 612023

    KEGG: hsa:55432

    STRING: 9606.ENSP00000326813

    UniGene: Hs.567533



主站蜘蛛池模板： 中文天堂在线资源www| 人妻 日韩 欧美 综合 制服| 天堂中文8资源在线8| 亚洲 欧美 另类图片| 亚洲 欧美精品suv| 国产草草影院ccyycom| 亚洲精品字幕在线观看| 潮喷大喷水系列无码视频| 午夜人成免费视频| 一区二区国产高清视频在线| 精品 日韩 国产 欧美 视频| 亚洲综合狠狠丁香五月| 国内少妇高潮嗷嗷叫在线播放| 国产成人无码a区视频在线观看| 欧美在线看片a免费观看 | 日本一本二本三区免费| 免费观看的av在线播放| 久久精品国产只有精品2020| 欧美精品一区二区三区在线| 亚洲成av人在线视| 日韩精品无码一区二区三区视频| 无码av高潮喷水无码专区线| 一区二区三区在线 | 欧洲| 亚洲人成网站在线播放2019| 中文字幕一区二区精品区| mm1313亚洲国产精品无码试看 | 欧美变态另类牲交| 亚洲国产精品一区二区成人片国内| 欧美激情一区二区三区在线| 免费无码av片在线观看潮喷| 亚洲日韩乱码中文无码蜜桃臀网站| 久久精品蜜芽亚洲国产av| 国内精品伊人久久久久av| 一边做一边喷17p亚洲乱妇50p | 亚洲精品无码一区二区| 色综合天天综合网中文| 亚洲精品国产一二三无码av| 久久婷婷五月综合色国产| 护士的小嫩嫩好紧好爽| 人妻中出无码一区二区三区| 4399理论片午午伦夜理片|