在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. YME1L1 Antibody
  • 中文名稱：
    YME1L1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA026267GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    YME1L1
  • 別名：
    YME1L1; FTSH1; YME1L; UNQ1868/PRO4304; ATP-dependent zinc metalloprotease YME1L1; ATP-dependent metalloprotease FtsH1; Meg-4; Presenilin-associated metalloprotease; PAMP; YME1-like protein 1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human YME1L1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required for normal, constitutive degradation of PRELID1. Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1).
  • 基因功能參考文獻(xiàn)：
    1. Data show that engineered YME1L protease discriminates between degradation signals by amino acid composition, implying the use of sequence-specific signals in mitochondrial proteostasis. PMID: 27786171
    2. These results identify mutations in YME1L1 as a cause of a mitochondriopathy with optic nerve atrophy highlighting the importance of YME1L1 for mitochondrial functionality in humans. PMID: 27495975
    3. YME1L1 was identified as the first NUMT (nuclear mtDNA) suppressor gene in human and demonstrate that inactivation of YME1L1 induces migration of mtDNA to the nuclear genome. PMID: 28356157
    4. differential stress-induced degradation of YME1L and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults. PMID: 26923599
    5. YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress.Loss of YME1L compromises the regulation of mitochondrial inner membrane proteostasis. PMID: 25433032
    6. Results reveal a crucial role for YME1L in the maintenance of mitochondrial inner-membrane proteostasis and in the proteolytic regulation of respiratory chain biogenesis. PMID: 22262461

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Optic atrophy 11 (OPA11)
  • 亞細(xì)胞定位：
    Mitochondrion inner membrane. Mitochondrion.
  • 蛋白家族：
    AAA ATPase family; Peptidase M41 family
  • 組織特異性：
    High expression in cardiac and skeletal muscle mitochondria.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12843

    OMIM: 607472

    KEGG: hsa:10730

    STRING: 9606.ENSP00000318480

    UniGene: Hs.499145



主站蜘蛛池模板： 日本中文字幕亚洲乱码| 国产成人av乱码免费观看| 国产作爱视频免费播放| 日韩精品人成在线播放| 国产精品乱码一区二区三区| 国产片精品av在线观看夜色| 99久久久国产精品消防器材 | 亚洲蜜桃精久久久久久久久久久久| 老熟妇仑乱一区二区视頻| 狂野av人人澡人人添| 日射精情感性色视频| 亚洲精品鲁一鲁一区二区三区| 天天躁日日躁很很很躁| 国产蝌蚪视频一区二区三区| a级大胆欧美人体大胆666| 人妻丰满熟妇av无码区app| 久久精品噜噜噜成人| 国产av亚洲精品久久久久久| 在线天堂免费观看.www| 中文字幕无码乱码人妻系列蜜桃| 亚洲精品国产电影| 乱中年女人伦av二区 | 成人试看120秒体验区| 久久综合九色欧美综合狠狠| 精品aⅴ一区二区三区| 久久99亚洲精品久久频| 色拍拍欧美视频在线看| 暖暖 免费 高清 日本 在线| 婷婷激情综合色五月久久竹菊影视| 日本中文字幕亚洲乱码| 日韩丰满少妇无吗视频激情内射| 国色天香社区视频手机免费| 亚洲乱色熟女一区二区三区丝袜 | 18禁亚洲深夜福利人口| 无码a∨高潮抽搐流白浆| 国产特黄级aaaaa片免| 国产人妻黑人一区二区三区| 337p日本欧洲亚洲大胆艺术图| 中文字幕乱码免费| 蜜臀av午夜一区二区三区| 精品国产一区二区三区av孞弋|