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WTAP Antibody

  • 中文名稱:
    WTAP兔多克隆抗體
  • 貨號:
    CSB-PA722026
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HUVEC cells, using WTAP antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) WTAP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WTAP
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from C-terminal of Human WTAP.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.
  • 基因功能參考文獻:
    1. WTAP was over-expressed in glioma tissues, and the expression was closely correlated with glioma grade. PMID: 27370540
    2. WTAP as a regulatory subunit is required for formation of a functional m6A methyltransferase complex including METTL3 and METTL14, which play an important role in the regulation of gene expression and alternative splicing. PMID: 24407421
    3. WTAP regulates migration and invasion of cholangiocarcinoma cells. PMID: 23354623
    4. WTAP has an important role in abnormal proliferation and arrested differentiation of leukemia cells, and WTAP is a novel client protein of Hsp90 PMID: 24413322
    5. the WTAP complex is a novel component of the RNA processing machinery, implying an important role in both posttranscriptional control and cell cycle regulation. PMID: 24100041
    6. WTAP overexpression made cancer cells more tumorigenic PMID: 22957919
    7. WTAP level in poodocytes is a valuable alternative technique in the study of podocyte injury in diabetic nephropathy. PMID: 19969384
    8. WTAP protein involved in the morphogenesis of the genitourinaty tract and in the etiology of isolated hypospadias. PMID: 14675924
    9. WTAP and ATF3 Transcription Factor are activated in Wilms' tumor and accelerate tumorigenesis. PMID: 16912181
    10. WTAP as an essential factor for the stabilization of cyclin A2 mRNA, thereby regulating G2/M cell-cycle transition PMID: 17088532
    11. WTAP is a novel regulator of the cell cycle and cell survival and implicate a WTAP-WT1 axis as a novel pathway for controlling vascular smooth muscle cell phenotype. PMID: 17095724
    12. Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival PMID: 19605357

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  • 亞細胞定位:
    Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm.
  • 蛋白家族:
    Fl(2)d family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 16846

    OMIM: 605442

    KEGG: hsa:9589

    STRING: 9606.ENSP00000351141

    UniGene: Hs.446091



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