在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WSB1 Antibody

  • 中文名稱:
    WSB1兔多克隆抗體
  • 貨號:
    CSB-PA026153GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    WSB1
  • 別名:
    WSB1 antibody; SWIP1 antibody; WD repeat and SOCS box-containing protein 1 antibody; WSB-1 antibody; SOCS box-containing WD protein SWiP-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human WSB1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.
  • 基因功能參考文獻:
    1. howed that miR-592 directly binds to the 3'-UTR of the WSB1 gene, thus disrupting hypoxia inducible factor-1alpha (HIF-1alpha) protein stabilization PMID: 27153552
    2. WSB1 is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier. PMID: 27958289
    3. WSB1 in glucose metabolism, and perhaps in mediating the Warburg effect in cancer cells by maintaining the function of HIF1. PMID: 27542736
    4. Our findings show how WSB1 regulates key steps of the metastatic cascade in hypoxia-driven osteosarcoma PMID: 26424695
    5. WSB1 up-regulates the expression of HIF-1alpha's target genes and promotes cancer invasion and metastasis through its effect on pVHL PMID: 26545811
    6. combination of WSB1(3) silencing together with WSB1 isoforms 1+2 silencing in NB cells showed reduced growth, enhanced apoptosis rate, and increased sensitivity to chemotherapeutic agents, specifically related to low expression of WSB1 PMID: 24441107
    7. HIF1 has a role in regulating WSB-1 expression, which promotes hypoxia-induced chemoresistance in hepatocellular carcinoma cells PMID: 23792163
    8. WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2). PMID: 15965468
    9. WSB1 shows strong correlations between expression level and copy number, and also enhances the prognostic prediction when combined with other current prognostic factors in neuroblastoma. PMID: 16804916
    10. the regulatory mechanisms by which HIPK2 is maintained at a low level, by WSB-1 in cells under normal conditions, and stabilized by genotoxic stresses. PMID: 18093972
    11. Data on WSB1 regulation support the hypothesis that activation of stress-response mechanisms helps cancer cells establishing metastases and suggest relevance to cancer development of other genes overexpressed in xenografts PMID: 18575577

    顯示更多

    收起更多

  • 數據庫鏈接:

    HGNC: 19221

    OMIM: 610091

    KEGG: hsa:26118

    STRING: 9606.ENSP00000262394

    UniGene: Hs.446017



主站蜘蛛池模板: 玩弄中年熟妇正在播放| 午夜免费啪在线观看视频| 国产深夜男女无套内射| 国产97色在线 | 亚洲| 国产精品刮毛| av免费播放一区二区三区| 亚洲成_人网站图片| 国产亚av手机在线观看| 天堂中文在线资源| 国产v综合v亚洲欧| 国产婷婷综合在线视频| 国产又大又黑又粗免费视频| 日韩久久无码免费毛片软件| 午夜视频在线在免费| 国内精品伊人久久久久网站| 国产一线二线三线女| 妺妺窝人体色777777| 天天躁日日躁狠狠躁性色av| 柠檬福利第一导航在线| 国产熟妇高潮叫床视频播放| 无遮挡激情视频国产在线观看| 在线观看国产丝袜控网站| 色天使久久综合网天天| 日本少妇高潮喷水视频| 人妻丰满熟妇a无码区| 亚洲成a人片在线观看你懂的| 欧美成人看片黄a免费看| 任你干视频精品播放| 久久精品女同亚洲女同| 内射后入在线观看一区| 色狠狠av一区二区三区| 日日碰狠狠添天天爽超碰97| 亚洲一区二区三区尿失禁| 中文字幕人妻高清乱码| 日韩av毛片无码免费| 九九视频免费精品视频| 久久伊人五月丁香狠狠色| 无码不卡中文字幕av| 正在播放国产乱子伦最新视频| 极品少妇xxxx| 欧美乱强伦xxxxx高潮|