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  4. WRNIP1 Antibody

WRNIP1 Antibody

  • 中文名稱：
    WRNIP1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA026150GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    WRNIP1
  • 別名：
    ATPase WRNIP 1 antibody; ATPase WRNIP1 antibody; bA420G6.2 antibody; FLJ22526 antibody; Putative helicase RUVBL antibody; RP11 420G6.2 antibody; Werner helicasae interacting protein 1 antibody; Werner helicasae interacting protein antibody; Werner helicase interacting protein isoform 2 antibody; Werner helicase-interacting protein 1 antibody; WHIP antibody; WRIP1_HUMAN antibody; WRNIP 1 antibody; WRNIP antibody; Wrnip1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human WRNIP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.
  • 基因功能參考文獻(xiàn)：
    1. findings define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral immunity. PMID: 29053956
    2. The authors show that WRNIP1 is directly involved in preventing uncontrolled MRE11-mediated degradation of stalled replication forks by promoting RAD51 stabilization on ssDNA. PMID: 27242363
    3. We propose that UBZ domains can be divided into at least two different types in terms of the ubiquitin-binding surfaces: the pol type and the WRNIP1 type PMID: 27062441
    4. results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation PMID: 25139235
    5. Mutated WRNIP1 with a deleted ATPase domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation. PMID: 22209848
    6. WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC) and set forth to investigate a role for the protein positioned at the NPC. PMID: 20676042
    7. These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta-mediated DNA synthesis and that its ATPase activity is utilized to sense DNA ends and to regulate the extent of stimulation. PMID: 15670210
    8. Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain PMID: 17550899
    9. analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions PMID: 18842586

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    AAA ATPase family, RarA/MGS1/WRNIP1 subfamily
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20876

    OMIM: 608196

    KEGG: hsa:56897

    STRING: 9606.ENSP00000370150

    UniGene: Hs.236828



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