在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WNK4 Antibody, Biotin conjugated

  • 中文名稱:
    WNK4兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA842690LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) WNK4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WNK4
  • 別名:
    PHA 2B antibody; PHA2B antibody; PRKWNK 4 antibody; PRKWNK4 antibody; Protein kinase lysine deficient 4 antibody; Protein kinase lysine-deficient 4 antibody; Protein kinase with no lysine 4 antibody; Serine/threonine protein kinase WNK4 antibody; Serine/threonine-protein kinase WNK4 antibody; WNK lysine deficient protein kinase 4 antibody; Wnk4 antibody; WNK4_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition.
  • 基因功能參考文獻(xiàn):
    1. 5 WNK4 sites (S47, S64, S1169, S1180, S1196) are phosphorylated downstream of AngII signaling in cultured cells and in vitro by PKC and PKA. Phosphorylation at S64 and S1196 promoted phosphorylation of the WNK4 kinase T-loop at S332 (required for kinase activation) and increased phosphorylation of SPAK. Volume depletion induced phosphorylation of these sites in vivo, predominantly in the distal convoluted tubule. PMID: 28096417
    2. Modulation of WNK4 activity by [Cl]i can account for its dual role on the NCC, and this has important physiological implications regarding the regulation of extracellular potassium concentration. PMID: 27322883
    3. This study provides substantial new insights into the role of phosphorylation of KLHL3 in regulating the interaction with WNK4 PMID: 27727489
    4. The distribution of allele frequency and genotype of WNK4 gene Ala589Ser polymorphism showed significant differences between essential hypertension subjects, with or without type 2 diabetes mellitus, and normotensive subjects. PMID: 27314050
    5. Data indicate that WNK lysine deficient protein kinase 4 protein (WNK4) was degraded not only by proteasomes but also by atypical protein kinase C scaffold protein p62 (p62)-kelch-like 3 protein (KLHL3)-mediated selective autophagy. PMID: 26349538
    6. this meta-analysis suggested that WNK4 G1155942T and C6749T gene polymorphisms may contribute to the susceptibility and development of hypertension. PMID: 25266424
    7. Akt and PKA phosphorylated KLHL3 at S433, and phosphorylation of KLHL3 by PKA inhibited WNK4 degradation. PMID: 26435498
    8. WNK4 is a substrate of SFKs and the association of c-Src and PTP-1D with WNK4 at Tyr(1092) and Tyr(1143) plays an important role in modulating the inhibitory effect of WNK4 on ROMK PMID: 25805816
    9. WNK4 inhibits SNARE formation of syntaxin 13 with VAMP2. PMID: 23993962
    10. Regulation of WNK4 by CUL3 and its relationship to blood pressure regulation and electrolyte homeostasis. [Review] PMID: 24518042
    11. WNK4 inhibits Large-conductance, Ca(2 )-activated K( ) channel activity, in part, by increasing channel degradation through an ubiquitin-dependent pathway. PMID: 23885063
    12. analysis of how mutations of KLHL3 show less ability to ubiquitinate WNK4 because of KLHL3's low stability and/or decreased binding to CUL3 or WNK4 PMID: 23962426
    13. WNK4 inhibits ENaC channel activity independently of Nedd4-2-mediated ENaC ubiquitination. PMID: 23594824
    14. KLHL3 is a substrate adaptor for WNK4 in a ubiquitin E3 ligase complex PMID: 23665031
    15. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. PMID: 23387299
    16. The Exon 8 G1155942T polymorphism in WNK4 gene was associated with hypertension in the Kazakhs ethnic group in Xinjiang, and the T allele might be the risk factor for essential hypertension. PMID: 20513278
    17. R1185C mutation disrupts a CaM binding site at the WNK4 COOH-terminal region and alters the phosphorylation of WNK4 by SGK1. PMID: 23054253
    18. Data show that K1169E lost its inhibitory effect on NCC surface expression compared to wild-type WNK4 when expressed in HEK293 cells, while it did not change NCC total protein expression. PMID: 21196779
    19. Results show that Tyr512 phosphorylation is a novel signal regulating the prevalence of CFTR at the cell surface and that WNK4 and Syk perform an antagonistic role in this process. PMID: 21807898
    20. WNK4 WT inhibits Maxi K activity by reducing Maxi K protein at the membrane, but the inhibition is not due to an increase in clathrin-mediated endocytosis of Maxi K, but likely due to enhancing its lysosomal degradation. PMID: 21613417
    21. WNK4 polymorphism rs56116165 is a rare allelic variant that may contribute to a genetic predisposition to osteoporosis PMID: 21236712
    22. Data show that 17beta-estradiol/ERalpha regulates human WNK4 expression partly through AP-1 binding to the WNK4 promoter. PMID: 20943203
    23. WNK4 kinase negatively regulates the anterograde trafficking of MR through kinase-independent mechanism. PMID: 21118716
    24. Exon 7 C1155547T polymorphism in WNK4 gene is associated with essential hypertension. PMID: 20931534
    25. The data demonstrate the hWNK4 3'-UTR plays an enhancer role by crosstalking with the promoter, and miR-296 suppresses hWNK4 expression through targeting on its 3'-UTR in a cell-specific fashion. PMID: 20561597
    26. Data find that expression of the N termini of all four WNKs results in modest to strong activation of SGK1. PMID: 20525693
    27. WNK4 promotes sodium chloride co-transporter targeting to the lysosome for degradation via a mechanism involving sortilin. PMID: 19875813
    28. WNK4 suppresses plasma membrane expression of the thiazide-sensitive NaCl cotransporter (NCC), diverting it from the trans-Golgi network to the lysosome via an intracellular route. PMID: 19401467
    29. The WNK4 gene probably plays an important role in the pathogenesis of essential hypertension. As a missense mutation, the Ala589Ser polymorphism may bring changes to the enzyme's function(s), resulting in increased susceptibility to the disease. PMID: 19340547
    30. Single-nucleotide polymorphims of WNK4 in whites and African Americans with hypertension. PMID: 12719438
    31. general role for WNK4 in the regulation of electrolyte flux in diverse epithelia PMID: 14769928
    32. The WNK4 mutant possesses a gain-of-function activity and that the claudins may be important molecular targets of WNK4 kinase. PMID: 15070779
    33. Mutations in the WNK4 gene identified in Japanese hypertensives may contribute to hypertension and progression of hypertensive complications to some extent. PMID: 15110905
    34. In familial hyperkalemia and hypertension with WNK4 mutations, all affected subjects will apparently develop hypertension. Hypercalciuria accompanies hyperkalemia, and both precede hypertension. WNK4 may interact with a calcium channel or transporter. PMID: 15292344
    35. data suggest that WNK4 wild type significantly inhibits sodium chloride cotransporter (NCC) surface expression, not owing to an increase in clathrin-mediated endocytosis of NCC, but likely from enhanced degradation of NCC through a lysosomal pathway PMID: 16688122
    36. an SGK1 site in WNK4 regulates Na+ channel and K+ channel activity PMID: 17360471
    37. WNK4 regulates transport proteins in different directions and cellular mechanisms. Familial hyperkalemic hypertension-causing mutants of WNK4 exhibit differences regulating ion transport proteins. PMID: 17634397
    38. Data demonstrate that WNK4 is a new glucocorticoid-regulated gene whose expression is inhibited through the interaction of glucocorticoid receptor with negative glucocorticoid response elements in the promoter region. PMID: 18096992
    39. WNK4-induced MAP kinase stimulation caused by hypertonicity PMID: 18312414
    40. These results confirm the important role of the acidic motif of WNK4 in its protein-protein interaction with the ROMK channel. PMID: 18755144
    41. using real-time PCR and Western blot assays, we show that trichostatin A (TSA), a histone deacetylase inhibitor, upregulated hWNK4 mRNA and protein expression in human embryo kidney 293 cells. PMID: 18793746
    42. identified P561L WNK4 mutation which has not been described previously is the probable cause of pseudohypoaldosteronism type II PMID: 19016006
    43. c-Src inhibits SGK1-mediated phosphorylation hereby restoring the WNK4-mediated inhibition of ROMK channels thus suppressing K secretion. PMID: 19706464

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Pseudohypoaldosteronism 2B (PHA2B)
  • 亞細(xì)胞定位:
    Cell junction, tight junction.
  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily
  • 組織特異性:
    Expressed in kidney, colon and skin.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14544

    OMIM: 601844

    KEGG: hsa:65266

    STRING: 9606.ENSP00000246914

    UniGene: Hs.105448



主站蜘蛛池模板: 国产偷窥熟女精品视频| 性久久久久久久| 国产av国片精品| 少妇做爰免费视频网站| 中文字幕人成乱码熟女香港 | 国产亚洲人成无码网在线观看| 日本黄漫动漫在线观看视频| 牲交a欧美牲交aⅴ免费一| 波多野结衣av在线观看| 又色又爽又高潮免费视频观看 | 亚洲乱码卡一卡二卡新区中国| 亚洲精品在看在线观看 | 久久九九久精品国产免费直播| 久久精品国产99国产精品澳门| 精品黑人一区二区三区| 人妻无码一区二区三区tv| 亚洲人成人一区二区三区| 波多野av一区二区无码| 国产成人精品电影在线观看 | 亚洲日韩国产二区无码| 欧美牲交a欧美牲交vdo18| 久久99精品国产99久久6| 欧美乱大交xxxxx疯狂俱乐部| 久久中文字幕人妻熟av女| 香蕉午夜福利院| 韩国无码av片在线观看| 国产在线精品一品二区| 亚洲成av人片在www色猫咪| 亚洲成av人在线视| 亚洲国产精品国语在线| 天堂8а√中文在线官网| 9lporm自拍视频区| 蜜臀av在线观看| 最新中文字幕av无码专区| 亚洲午夜私人影院在线观看| 国产成人亚洲精品无码最新 | 欧美成人精品 一区二区三区| 无码精品国产va在线观看| 色拍拍在线精品视频| 国产一区二区无码蜜芽精品| 久热中文字幕无码视频|