在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WNK3 Antibody, FITC conjugated

  • 中文名稱:
    WNK3兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA861176LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) WNK3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WNK3
  • 別名:
    KIAA1566 antibody; PRKWNK 3 antibody; PRKWNK3 antibody; Protein kinase lysine deficient 3 antibody; Protein kinase lysine-deficient 3 antibody; Protein kinase with no lysine 3 antibody; Serine/threonine protein kinase WNK3 antibody; Serine/threonine-protein kinase WNK3 antibody; WNK 3 antibody; WNK lysine deficient protein kinase 3 antibody; Wnk3 antibody; WNK3_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Serine/threonine-protein kinase WNK3 protein (1018-1181AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.; Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.
  • 基因功能參考文獻(xiàn):
    1. Data show that WNK lysine deficient protein kinase 3 protein (WNK3) interacts with NCC and increases the Na-Cl cotransporter (NCC) expression on the cell membrane and in cytoplasm together. PMID: 27378340
    2. WNK3 enhances NCC protein expression by increasing NCC synthesis via an ERK 1/2-dependent signaling pathway PMID: 27467688
    3. WNK3 knockout mice exhibited significantly decreased infarct volume in a transgenic model of stroke and brain damage. PMID: 26069258
    4. There may be a novel role for WNK3 on the renal Na+-Cl-cotransporter (NCC) expression at the plasma membrane, an effect apparently independent of the SPAK kinase and the aldosterone-SGK1 pathway. PMID: 24920754
    5. LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity. PMID: 23482566
    6. WNK3 modulates intracellular Cl(-) concentration and regulatory volume decrease in HEK293 cells. PMID: 22864523
    7. Analysis of the data showed that WNK3 is an essential regulator of NKCC1 and that WNK3 activates NKCC1-mediated ion transport necessary for cell volume changes associated with cell invasion. PMID: 21813709
    8. OXSR1 and WNK3 transcripts were substantially overexpressed in subjects with schizophrenia relative to comparison subjects. PMID: 20819979
    9. WNK3 lies within the critical linkage interval for several human monogenic disorders, including X-linked mental retardation. The function of mammalian WNK3 kinase remains to be investigated. PMID: 15194194
    10. WNK3 is involved in promoting cell survival by a mechanism at the level of procaspase-3 activation. PMID: 16501604
    11. Results report that WNK3, another member of the WNK kinase family expressed by distal tubule cells, interacts with WNK4 and WNK1 to regulate NCC in both human kidney cells and Xenopus oocytes. PMID: 17975670
    12. The positive effect of WNK3 on NCC also requires its catalytic activity PMID: 18701621
    13. WNK3 is a positive regulator of the transcellular Ca2+ transport pathway (TRPV5 and TRPV6). PMID: 18768590
    14. The C-terminal motifs contributed by exons 18 and 22 play an important role in the actions of WNK3 isoforms on NCCT. PMID: 19470686

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily
  • 組織特異性:
    Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific. Isoform 3
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14543

    OMIM: 300358

    KEGG: hsa:65267

    STRING: 9606.ENSP00000346667

    UniGene: Hs.92423



主站蜘蛛池模板: 欧美另类又黄又爽的a片 | 忘忧草影院在线www韩国日本| 亚洲全部无码中文字幕| 国产最大成人亚洲精品| 北条麻妃在线一区二区| 无码不卡av东京热毛片| 国产精品乱码一区二区三| 久久久久欧美国产高潮| 日本黄漫动漫在线观看视频| 最新中文乱码字字幕在线| 无码免费一区二区三区| 精品无码三级在线观看视频| 夜夜爱夜夜做夜夜爽| 国产成人精品一区二区三区免费看| 综合激情五月综合激情五月激情1| 午夜dv内射一区二区| 中文字幕人妻中文av不卡专区| 日本亚洲色大成网站www| 久久久橹橹橹久久久久高清| 日韩精品亚洲人旧成在线| 国产精品亚亚洲欧关中字幕| 亚洲电影在线观看| 亚洲人午夜射精精品日韩| 美女视频黄的全免费视频网站 | 国产麻豆成人传媒免费观看| 国产真实乱人偷精品视频| 中国肥老太婆高清video| 97国产一区二区三区四区久久| 久久国产成人精品av| 娇妻玩4p被三个男人伺候电影| 中文字幕人妻无码专区| 国产清纯美女遭强到高潮| 欧美牲交a欧美牲交aⅴ| 成人性生交大片免费看视频app| 成人综合婷婷国产精品久久 | 久久久精品2019免费观看| 欧美日产国产精品日产| 熟女少妇人妻中文字幕| 中国女人内射6xxxxx| 亚洲乱码卡一卡二卡新区中国 | 国产又黄又大又粗视频|