在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. WNK2 Antibody, Biotin conjugated

WNK2 Antibody, Biotin conjugated

  • 中文名稱：
    WNK2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA896509LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) WNK2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    WNK2
  • 別名：
    WNK2 antibody; KIAA1760 antibody; PRKWNK2 antibody; SDCCAG43 antibody; P/OKcl.13 antibody; Serine/threonine-protein kinase WNK2 antibody; EC 2.7.11.1 antibody; Antigen NY-CO-43 antibody; Protein kinase lysine-deficient 2 antibody; Protein kinase with no lysine 2 antibody; Serologically defined colon cancer antigen 43 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
  • 基因功能參考文獻(xiàn)：
    1. WNK2 promoter methylation and silencing in gliomas is associated with increased JNK activation and MMP2 expression and activity, thus explaining in part tumor cell invasion potential. PMID: 25596741
    2. Downregulation of WNK2 by promoter hypermethylation occurs early in Pancreatic ductal adenocarcinoma pathogenesis and may support tumor cell growth via the ERK-MAPK pathway. PMID: 23912455
    3. results validate the WNK2 gene as a recurrent target for epigenetic silencing in glia-derived brain tumours and provide first mechanistic evidence for a tumour-suppressing role of WNK2 that is related to Rac1 signalling and tumour cell invasion and growth PMID: 23035050
    4. a role for WNK2 in the regulation of CCCs in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling. PMID: 21733846
    5. epigenetic silencing, occasional deletion and point mutation, and functional assessment suggest that aberrations of WNK2 may contribute to unregulated tumor cell growth PMID: 17578925
    6. WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway. PMID: 17667937
    7. WNK2 controls a RhoA-mediated cross-talk mechanism that regulates the efficiency with which MEK1 can activate ERK1/2 upon growth factor stimulation. PMID: 18593598
    8. Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. PMID: 19001526

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily
  • 組織特異性：
    Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14542

    OMIM: 606249

    KEGG: hsa:65268

    STRING: 9606.ENSP00000297954

    UniGene: Hs.654856



主站蜘蛛池模板： 亚洲综合av一区二区三区不卡| 国产美女极度色诱视频www| 色欲一区二区三区精品a片| 欧美亚洲国产精品久久| 国产精品美女乱子伦高潮| 无遮挡边吃摸边吃奶边做| 丰满人妻妇伦又伦精品国产| 免费午夜无码片在线观看影院| 精品免费国产一区二区| 99re久久精品国产首页| 亚洲精品一区二区久| 成人试看30分钟免费视频| 精品国产v无码大片在线观看| 久久99热久久99精品| 国产一区二区不卡老阿姨| 国产玉足脚交极品在线播放| 女人夜夜春高潮爽a∨片| 日产精品久久久一区二区| 三级视频兔费看| 国产美女a做受大片观看| 女人被爽到高潮视频免费国产| 免费无码又爽又高潮视频| 国产又爽又黄又不遮挡视频| 国产最新精品自产在线观看| 人妻换人妻a片爽麻豆| 色综合欧美在线视频区| 精品久久一区二区乱码 | 国精产品蘑菇一区一区有限| 免费无码又爽又刺激网站| 亚洲欧洲美洲无码精品va| 日产欧美国产日韩精品| 久久精品水蜜桃av综合天堂| 国产麻豆精品一区二区三区v视界| 国产精品亚洲精品日韩已满十八小| 国内精品久久久久久久电影视| 国产精品丝袜黑色高跟鞋| 成片免费观看视频大全| 亚洲一区二区三区无码av| 人人妻人人澡人人爽人人精品| 亚洲国产精品久久网午夜 | 国产精品人成视频免费999|