在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WISP2 Antibody

  • 中文名稱:
    WISP2兔多克隆抗體
  • 貨號:
    CSB-PA968927
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from A549, A431 cells using WISP2 Antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) WISP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WISP2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence around aa.242~246(G-R-S-P-Q) derived from Human WISP2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
  • 基因功能參考文獻:
    1. The authors show that, in triple-negative-breast cancer (TNBC) cells enriched with tumor initiating cells, CCN5 significantly blocks cellular growth via apoptosis, reversing epithelial-mesenchymal-transition-signaling and impairing mammosphere formation, thereby blocking the tumor-forming ability and invasive capacity of these cells. PMID: 28450698
    2. by analyzing different estrogen receptor-alpha(ER-a)-positive and ER-a-negative breast cancer cell lines, we defined the role of CCN5 in the leptin-mediated regulation of growth and invasive capacity. PMID: 29370782
    3. CCN3 (Nov) and CCN5 (WISP2) are novel substrates of MMP14. PMID: 27471094
    4. Results show that WISP2 and beta-catenin were more highly expressed in gastric cancer tissues and seem to correlate with early stage or without metastasis. PMID: 28739741
    5. Report opposing effects of CCN2 and CCN5 on fibroblast proliferation and transdifferentiation induced by TGF-beta. PMID: 26218313
    6. Serum WISP2 correlated directly with fatty acid binding protein 4. Serum SFRP5 did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (p<5x10(-6) as compared to both PCOS groups). PMID: 25089371
    7. Activation of CCN5 may have the therapeutic potential to kill triple-negative breast cancer. PMID: 25132260
    8. WISP2 has a role in regulating tumor cell susceptibility through EMT by inducing the TGF-beta signaling pathway, KLF-4 expression and miR-7 inhibition. PMID: 24931170
    9. The obtained results indicate that the changes in gene expression in bone marrow progenitor cells can be involved into space flight-induced osteopenia. PMID: 25509878
    10. overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer. PMID: 23592278
    11. Loss of WISP2 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype. PMID: 24498388
    12. We demonstrate that the overexpression of CCN5 in lung fibroblasts suppresses the upregulation in the expression of alpha-SMA and collagen induced by CCN2. PMID: 24276150
    13. WISP2 exerts dual actions in mesenchymal precursor cells; secreted WISP2 activates canonical WNT and maintains the cells in an undifferentiated state, whereas cytosolic WISP2 regulates adipogenic commitment. PMID: 24451367
    14. Regulation of invasion by WISP2 may involve the WNT signalling pathway. PMID: 23893926
    15. WISP2 regulates preadipocyte commitment and PPARgamma activation by BMP4. PMID: 23359679
    16. WISP2 gene expression is regulated both by obesity and by the region between visceral and subcutaneous adipose tissue. PMID: 22616691
    17. Studies suggest a novel regulatory pathway exists through which CCN5 exerts its anti-invasive function. PMID: 22020939
    18. CCN5 represses expression of genes associated with epithelial-mesenchymal transition (EMT) as well as expression of key components of the transforming growth factor beta (TGF-beta) signaling pathway. PMID: 21262769
    19. The CCN5/WISP2 were downregulated in paired comparisons of plexiform neurofibroma and malignant peripheral nerve sheath tumor. PMID: 20010302
    20. Overexpression of WISP2 is associated with breast cancer PMID: 11855747
    21. disruption of WISP-2 signaling by use of antisense oligomers caused a significant reduction in breast tumor cell proliferation PMID: 12659671
    22. WISP2 was overexpressed in gastrointestinal peptide-independent ACTH-independent macronodular adrenal hyperplasia. PMID: 14767469
    23. regulation of phosphorylation of ER-alpha and EGFR may play critical roles in EGF-induced transcriptional activation of WISP-2 gene in breast tumor cells PMID: 15798095
    24. These data demonstrate that the expression of WISP2 is synergistically upregulated in RA synovial fibroblasts by estrogen and WNT pathways, and suggest an involvement in the pathology of the disease. PMID: 16038875
    25. Results suggest that WISP-2 could be a reliable independent marker and that down-regulation or loss of the WISP-2 gene may be associated with the development of salivary gland tumors. PMID: 16525711
    26. WISP-2/CCN5 is a novel signaling molecule that critically participates in the mitogenic action of PMA on noninvasive, WISP-2/CCN5-positive breast tumor cells through PKCalpha-dependent, multiple molecular signal transduction pathways. PMID: 16939222
    27. Data suggest WISP-2/CCN5 silencing may be a critical event during differentiation and progression of pancreatic adenocarcinoma. PMID: 17383817
    28. WISP-2 had greater levels of expression in node-positive tumors; higher levels in both moderate and poor prognostic groups compared with the good prognostic group; greater level in both grade 2 and 3 when compared with grade 1. PMID: 17406949
    29. WISP-2/CCN5 is an important regulator involved in the maintenance of a differentiated phenotype in breast tumor epithelial cells and may play a role in tumor cell invasion and metastasis PMID: 18070926
    30. Loss of CCN5 is associated with gain of oncogenic function of p53 mutants invasiveness in breast cancer PMID: 18559502
    31. CCN5 mRNA and protein level was almost undetectable in poorly differentiated breast cancers compared with the moderately or well-differentiated samples and its expression inversely correlated with lymph node positivity. PMID: 18794149

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    CCN family
  • 組織特異性:
    Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.
  • 數據庫鏈接:

    HGNC: 12770

    OMIM: 603399

    KEGG: hsa:8839

    STRING: 9606.ENSP00000190983

    UniGene: Hs.592145



主站蜘蛛池模板: 丰满又黄又爽少妇毛片| 69久久精品无码一区二区| 乱码午夜-极品国产内射| 无码av免费一区二区三区a片| 国产成+人欧美+综合在线观看 | 破了亲妺妺的处免费视频国产| 荫蒂被男人添的好舒服爽免费视频| 少妇愉情理伦片丰满丰满午夜| 午夜私人成年影院在线观看| 亚洲综合激情七月婷婷| 国产伦精品免编号公布| 久久久老熟女一区二区三区| 国产精品边做奶水狂喷无码| 97狠狠狠狼鲁亚洲综合网| 男人扒开女人腿桶到爽免费| 日本久久久久久久做爰片日本| 无码国产精品高清免费| 99国产欧美另娄久久久精品| 国产成人无码www免费视频播放| 日本在线高清不卡免费播放| 99精品日本二区留学生| 国产精品乱码高清在线观看| 亚洲精品亚洲人成人网| 中文字幕人妻熟女av| 最新无码a∨在线观看| 国产精品区免费视频| 少妇被粗大的猛进69视频| 波多老师无码av中字专区| 亚洲精品亚洲人成在线下载| 丰满人妻被中出中文字幕| 2021国产精品视频网站| 一区二区三区国产精华液| 精品人妻系列无码人妻漫画| 国产精品美脚玉足脚交欧美| 18禁超污无遮挡无码免费网站国产 | 永久中文字幕免费视频网站| 国产一区二区三区不卡av| 国产69精品久久久久人妻刘玥| 少妇人妻中文字幕hd| 极品少妇小泬50pthepon| 国产精品久久777777|