在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. WIPF1 Antibody

WIPF1 Antibody

  • 中文名稱：
    WIPF1兔多克隆抗體
  • 貨號：
    CSB-PA060082
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    WIPF1 antibody; WASPIP antibody; WIP antibody; WAS/WASL-interacting protein family member 1 antibody; Protein PRPL-2 antibody; Wiskott-Aldrich syndrome protein-interacting protein antibody; WASP-interacting protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human WIP.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles. Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
  • 基因功能參考文獻(xiàn)：
    1. WIP deficiency should be considered as a cause for autosomal-recessive immunodeficiency PMID: 27742395
    2. the present study identifies the WIPF1 gene as having novel oncogenic functions and playing an important role in the invasiveness and aggressiveness of thyroid cancer when aberrantly up-regulated by the BRAF V600E/MAPK pathway through its promoter demethylation. PMID: 27863429
    3. WIP controls tumor growth by boosting signals that stabilize the YAP/TAZ complex via a mechanism mediated by the endocytic/endosomal system. PMID: 27851961
    4. Results suggest that local invasiveness of ameloblastoma is dependent upon the migratory potential of its tumour cells as defined by their distribution of cortactin, N-WASP and WIP in correlation with F-actin cytoskeletal dynamics. PMID: 26752341
    5. establish a new cancer stem cell signalling pathway downstream of mtp53 in which AKT2 regulates WIP and controls YAP/TAZ stability. PMID: 28166194
    6. Knocking down WIP expression in A549 cells significantly reduced RhoA levels and WIP was found to interact with RhoA suggesting that WIP might be executing its function by regulating RhoA. PMID: 27939884
    7. Study provides evidence that WIP and WIRE contribute to breast cancer cell invasiveness through coordinated roles. WIP seems necessary for the assembly of invasive protrusions, whereas WIRE regulates their maturation, which leads to matrix degradation. PMID: 27009365
    8. WIP was shown to interact with various binding partners, including the signaling proteins Nck, CrkL and cortactin. PMID: 22837718
    9. These findings reveal WIP as a previously unreported regulator of neuronal maturation and synaptic activity PMID: 21810783
    10. These findings indicate that WIP deficiency should be suspected in patients with features of WAS in whom WAS sequence and mRNA levels are normal. PMID: 22231303
    11. show that the N-WASP EVH1 domain specifically binds a 25 residue motif from the WASP Interacting Protein (WIP) PMID: 12437929
    12. Only in the presence of WASP-interacting protein (WIP) can human WASP suppress the growth defect of Saccharomyces cerevisiae las17Delta strain. PMID: 16488394
    13. A 1.3 mD multiprotein complex consisting of WASp-interacting protein (WIP), Wiskott-Aldrich syndrome protein (WASp), actin, and myosin IIA formigg during NK cell activation was identified with a role in complex formation and NK cell activity regulation. PMID: 16606694
    14. WASP-interacting protein stabilizes Wiskott-Aldrich syndrome protein(WASP) and suggest that it may also be important for its function PMID: 17213309
    15. In this review, in addition to its WASP-independent functions, the role of WIP is to regulate the activity and stability of WASP and shuttle WASP to areas of actin assembly. PMID: 17949983
    16. WIP is involved in lytic granule transport and is essential for regulation of Natural killer cell cytotoxic function PMID: 18258743
    17. Groups of colorectal cancer, breast cancer, and glioma patients with low expression of the WIPF1 co-expression module generally had a favorable prognosis. PMID: 19399471

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Wiskott-Aldrich syndrome 2 (WAS2)
  • 亞細(xì)胞定位：
    Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle.
  • 蛋白家族：
    Verprolin family
  • 組織特異性：
    Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12736

    OMIM: 602357

    KEGG: hsa:7456

    STRING: 9606.ENSP00000352802

    UniGene: Hs.128067



主站蜘蛛池模板： 亚洲乱亚洲乱妇50p| 日本无遮挡吸乳呻吟视频| 亚洲精品乱码久久久久久自慰| 波多野结衣办公室双飞| av无码一区二区大桥久未| 国产精品jk白丝在线播放| 18禁成年无码免费网站| 中文字幕亚韩| 欧美乱码精品一区二区三区| 狠狠色噜噜狠狠狠7777米奇| 亚洲人成网站18禁止一区| 国产成人久久精品77777综合| 深夜国产一区二区三区在线看 | 亚洲色偷偷偷网站色偷一区 | 日本高清www无色夜在线视频| 国产草草影院ccyycom| 欧美性受xxxx黑人xyx性爽| 亚洲精品综合一区二区三区在线| 国产精品欧美成人| 秋霞特色aa大片| 国产免费无码一区二区| 一本一道色欲综合网| 无码人妻一区二区三区av| 日本sm/羞辱/调教/捆绑视频| 日韩精品无码免费一区二区三区 | 亚洲日韩一区精品射精| 麻豆精品国产精华精华液好用吗| 四虎影视无码永久免费| √天堂中文最新版在线中文| 无码不卡av东京热毛片| 日本狂喷奶水在线播放212| 亚洲热妇无码av在线播放 | 2019午夜福利不卡片在线| 波多野结衣av手机在线观看| 国产亚洲精品久久久久动漫| 国产亚洲精品久久一区二区| 中文字幕丰满孑伦无码专区| 亚洲午夜私人影院在线观看| 亚洲精品国产一区二区图片| 久久av高清无码| 亚洲图片自拍偷图区|