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  4. WDR19 Antibody, Biotin conjugated

WDR19 Antibody, Biotin conjugated

  • 中文名稱：
    WDR19兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA836733LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) WDR19 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    WDR19
  • 別名：
    DYF 2 antibody; DYF2 antibody; FLJ23127 antibody; IFT144 antibody; Intraflagellar transport 144 homolog antibody; KIAA1638 antibody; ORF26 antibody; Oseg6 antibody; PWDMP antibody; WD repeat containing protein 19 antibody; WD repeat domain 19 antibody; WD repeat membrane protein PWDMP antibody; WD repeat-containing protein 19 antibody; Wdr19 antibody; WDR19_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human WD repeat-containing protein 19 protein (45-226AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly. Essential for functional IFT-A assembly and ciliary entry of GPCRs. Associates with the BBSome complex to mediate ciliary transport.
  • 基因功能參考文獻：
    1. Case Reports: that WDR19 mutations can cause dysplastic kidney in addition to nephronophthisis in infants with Sensenbrenner syndrome. PMID: 28621010
    2. Nephronophthisis 13 (Autosomal Recessive Polycystic Kidney Disease) is associated with mutations in the WDR19 gene.Caroli disease is a major extra-renal phenotype associated with mutations in WDR19 in the Korean population. PMID: 25726036
    3. WDR19 mutations can cause a broad spectrum of ciliopathies that extends to Jeune and Sensenbrenner syndromes, RP and renal NPHP-like phenotypes PMID: 24504730
    4. Mutations in WDR19 gene is associated with Caroli disease. PMID: 23559409
    5. WDR19: an ancient, retrograde, intraflagellar ciliary protein is mutated in autosomal recessive retinitis pigmentosa and in Senior-Loken syndrome. PMID: 23683095
    6. Ciliopathies with skeletal anomalies and renal insufficiency due to mutations in the IFT-A gene WDR19 PMID: 22019273
    7. Expressed in normal and neoplastic prostate epithelium and is regulated by androgenic hormones. PMID: 12906858
    8. Overexpression of WDR19 is associated with prostate cancer PMID: 18316561

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  • 相關疾病：
    Cranioectodermal dysplasia 4 (CED4); Short-rib thoracic dysplasia 5 with or without polydactyly (SRTD5); Nephronophthisis 13 (NPHP13); Senior-Loken syndrome 8 (SLSN8)
  • 亞細胞定位：
    Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, photoreceptor outer segment.
  • 組織特異性：
    Some isoforms are tissue-specific. Highly expressed in the prostate. Lower expression in the cerebellum, pituitary gland, fetal lung, and pancreas. In normal prostate, expressed in both basal and luminal epithelial cells. No expression detected in fibromu
  • 數據庫鏈接：

    HGNC: 18340

    OMIM: 608151

    KEGG: hsa:57728

    STRING: 9606.ENSP00000382717

    UniGene: Hs.438482



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