在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. WDHD1 Antibody

WDHD1 Antibody

  • 中文名稱：
    WDHD1兔多克隆抗體
  • 貨號：
    CSB-PA004488
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of Jurkat cells using WDHD1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    WDHD1
  • 別名：
    WDHD1 antibody; AND1 antibody; WD repeat and HMG-box DNA-binding protein 1 antibody; Acidic nucleoplasmic DNA-binding protein 1 antibody; And-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human WDHD1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.
  • 基因功能參考文獻：
    1. And-1 interacts with CtIP and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair. PMID: 27940552
    2. important role of And-1 in homologous recombination repair by regulating CtIP-mediated DNA double-strand break end resection PMID: 27940557
    3. findings provide important insights into the mechanistic details of human AND-1 function, advancing our understanding of replisome formation during eukaryotic replication. PMID: 28381552
    4. The WDHD1 gene, one of the genes that is upregulated in human papillomavirus E7-expressing cells, was found to play an important role in E7-induced G1 checkpoint abrogation and rereplication PMID: 27099318
    5. Results provide additional evidence suggesting that WDHD1 is involved in the mismatch repair pathway. PMID: 27037360
    6. RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells. PMID: 25602958
    7. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. PMID: 26082189
    8. The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex. PMID: 24255107
    9. And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres. PMID: 23184928
    10. Human And-1 facilitates loading of the MCM2-7 helicase onto chromatin during the assembly of prereplicative complex. PMID: 23093411
    11. Data show that And-1 forms a complex with both histone H3 and Gcn5. PMID: 21725360
    12. in human cells, hCtf4 plays an essential role in DNA replication and its ability to stimulate the replicative DNA polymerases may contribute to this effect PMID: 20089864
    13. Mcm10 is required for chromatin loading of And-1. PMID: 17761813
    14. AND-1 coordinates multiple cellular events in S phase and G2 phase. PMID: 19439411
    15. Assembly of the Cdc45-Mcm2-7-GINS complex requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. PMID: 19805216

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleoplasm.
  • 數據庫鏈接：

    HGNC: 23170

    OMIM: 608126

    KEGG: hsa:11169

    STRING: 9606.ENSP00000353793

    UniGene: Hs.385998



主站蜘蛛池模板： 国产mv在线天堂mv免费观看 | √天堂资源中文| 天堂资源中文| 亚洲精品一区二区三区中文字幕| 国产精品国产高清国产av| 国产成人亚洲精品| 亚洲欧洲无码av不卡在线| 最新在线精品国自产拍视频| 亚洲一区二区| 亚洲精品亚洲人成人网| 免费情侣作爱视频| 国产免费一区二区三区不卡 | 亚洲精品无码av黄瓜影视| 亚洲精品久久7777777国产| 少妇精品揄拍高潮少妇| а天堂中文在线官网| 乱码午夜-极品国产内射| 男女无遮挡猛进猛出免费观看视频| 极品人妻少妇一区二区三区| 少妇人妻精品一区二区三区| 囯产精品久久久久久久久久妞妞| 国产按头口爆吞精在线视频| 国产日韩一区二区三区在线观看| 伊人久久久精品区aaa片 | 欧美精品国产aⅴ一区二区在线 | 国产农村老太xxxxhdxx| 人人妻人人澡人人爽人人精品av| 色妺妺av爽爽影院| 国产精品av一区二区三区不卡蜜| 午夜在线观看免费线无码视频| 996久久国产精品线观看| 天堂√最新版中文在线天堂| 久久伊人av综合影院| 国产免费内射又粗又爽密桃视频| 国产精品成人嫩草影院| 丝袜高潮流白浆潮喷在线播放 | 国产亚洲久久久久久久| 熟女内射v888av| 无码av中文字幕免费放| 乌克兰性欧美精品高清| 午夜免费男女aaaa片|