在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

WASF3 Antibody, Biotin conjugated

  • 中文名稱:
    WASF3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào):
    CSB-PA891467LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) WASF3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    KIAA0900 antibody; Protein WAVE-3 antibody; Protein WAVE3 antibody; SCAR3 antibody; Verprolin homology domain containing protein 3 antibody; Verprolin homology domain-containing protein 3 antibody; WASF3 antibody; WASF3_HUMAN antibody; WASP family protein member 3 antibody; WAVE3 antibody; Wiskott Aldrich syndrome protein family member 3 antibody; Wiskott-Aldrich syndrome protein family member 3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Wiskott-Aldrich syndrome protein family member 3 protein (368-502AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
  • 基因功能參考文獻(xiàn):
    1. Study demonstrated that the expression levels of WAVE3 in pancreatic cancer tissues were prominently higher than those in the non-cancerous tissues which seems to be associated with lymphatic metastasis, poorly differentiated tumors. Furthermore, findings suggest that WAVE3 influences cell proliferation, migration and invasion via the AKT pathway. PMID: 29845225
    2. Results suggest that Wiskott-Aldrich syndrome verprolin-homologous protein 3 (WAVE3) may be pivotal in ovarian cancer cell motility, invasion and oncogenesis. PMID: 28476025
    3. p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion PMID: 28794159
    4. we show that WASF3 is present in the HER2 immunocomplex and suppression of WASF3 function leads to suppression of invasion even in the presence of HER2 expression.The engagement of WASF3 with the HER2/HER3 complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2/HER3 activation of JAK/STAT signaling. PMID: 26804171
    5. It was concluded that WAVE3 may represent a new adverse prognostic factor for patients with ICC. PMID: 26971088
    6. studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis PMID: 28233357
    7. Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 cells through their interaction with the ARP2/3 complex. PMID: 26977009
    8. stabilization of WASF3 function occurs through its interaction with ATAD3A and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles PMID: 25823022
    9. We show that WAVE3-mediated modulation of NFkappaB is required for invadopodia formation as well as MMP9 expression and activity that are needed for cancer cells to degrade the ECM PMID: 25329315
    10. WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells. PMID: 25661390
    11. WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail. PMID: 25378074
    12. miR-217 functions as a tumor-suppressive miRNA and inhibits the osteosarcoma tumorigenesis through targeting WASF3. PMID: 25289936
    13. Upregulated WAVE3 expression is essential for TGF-beta-mediated EMT and metastasis of triple-negative breast cancer cells. PMID: 24197660
    14. ZEB1/2 upregulation by WASF3 results from downregulation of KISS1, leading to the release of inhibition of nuclear factor (NF)kappaB by IkappaBalpha PMID: 23318438
    15. these results define a novel signaling network whereby JAK2/STAT3 signaling creates a feed-forward loop to raise activated WASF3 levels that promote cancer cell motility. PMID: 23677069
    16. MMP-9 and WAVE3 were over-expressed in colorectal cancer tissues compared with normal mucosa. PMID: 22806308
    17. demonstrate WASF3 is a HIF1A-regulated gene and suggests a mechanism to explain the observation of elevated expression of WASF3 in advanced stage tumors PMID: 22581642
    18. increased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancer PMID: 22952619
    19. WAVE3-depleted breast cancer cells move more slowly but more persistently on a 2-dimensional matrix. They typically only show one lamellipod. WAVE3 appears to have no role in driving invasiveness. Lamellipodial persistence is not crucial in 3-dimensions. PMID: 22909346
    20. HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein. PMID: 22315230
    21. coordinated expression patterns of the WASF3 metastasis promoter gene and the KISS1 metastasis suppressor gene appear to exert their influence through inhibition of NF-kappaB signaling, which in turn regulates MMP-9 production facilitating invasion. PMID: 21544801
    22. The study also identifies a critical role for WAVE3, downstream of miR-31, in the invasion-metastasis cascade. PMID: 21105030
    23. WAVE3 is pivotal in controlling the invasiveness of prostate cancer cells. PMID: 19395286
    24. Studies identified a novel mechanism for the regulation of WAVE3 expression in cancer cells, which controls the invasive properties and morphology of cancer cells associated with their metastatic potential. PMID: 19801681
    25. patient with ganglioneuroblastoma carries an apparently balanced t(1:13)(q21:q12) reciprocal translocation. Positional cloning of the translocation breakpoint on chromosome 13 resulted in the mapping of the breakpoint between coding exon 2 and 3 of WAVE3 PMID: 12185600
    26. during megakaryocytic differentiation, platelets expressed WAVE-1 and WAVE-2, whereas WAVE-3 expression was hardly to be detected. WAVE-3 expression was not changed by the differentiation PMID: 15670045
    27. all three Scar/WAVE isoforms behave similarly and are likely to participate in the same kinds of protein complexes that regulate actin assembly PMID: 15752430
    28. WAVE3-mediated migration in MDA-MB-231 cells via lamellipodia formation is activated downstream of PI3K and induced by PDGF PMID: 15826941
    29. The WAVE3 is a member of the WASP/WAVE family of proteins, which play a critical role in the regulation of actin polymerization, cytoskeleton organization, and cell motility. PMID: 15907837
    30. the activation of WAVE3 to promote actin remodeling is enhanced by the c-Abl-mediated tyrosine phosphorylation of WAVE3. PMID: 17623672

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    SCAR/WAVE family
  • 組織特異性:
    Expressed in ovary and brain.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 12734

    OMIM: 605068

    KEGG: hsa:10810

    STRING: 9606.ENSP00000335055

    UniGene: Hs.618732



主站蜘蛛池模板: 国产成人片无码免费视频软件| 粗了大了 整进去好爽视频| 日本老妇人乱xxy| 少妇被爽到高潮动态图| 狠狠色狠狠色综合日日不卡| 久久er热在这里只有精品66| 成人无码视频97免费| 亚洲风影视传媒有限公司辽宁| 日韩精品视频一区二区三区| 国产内射老熟女aaaa∵| 亚 洲 成 人 网站在线观看| 2022国产日产欧产精品| 成年女人永久免费观看视频| 日韩精品无码一区二区中文字幕| 综合无码精品人妻一区二区三区| 国产精品jk白丝在线播放| 日日摸天天摸爽爽狠狠97| 性欧美牲交在线视频| 午夜人妻理论片天堂影院| 久久国产精品成人片免费| 色婷婷久久综合中文久久蜜桃av | 久久综合九色综合久99| 日日碰狠狠躁久久躁蜜桃| 久久97国产超碰青草| 国产午夜福利院757视频| 国产精品自在拍首页视频| 熟女人妻aⅴ一区二区三区60路| 三上悠亚人妻中文字幕在线| 欧洲一卡2卡3卡4卡国产| 色噜噜噜亚洲男人的天堂| 中国女人做爰视频| 久久精品国产福利一区二区| 日韩av高潮喷水在线观看| 免费观看美女裸体网站| 国产午夜福利片| 国产丝袜在线精品丝袜| 欧美日韩亚洲中文字幕一区二区三区| 国产成人无码a区在线观看导航| 蜜臀av综合网| 欧美日韩无线码在线观看| 爆乳熟妇一区二区三区霸乳|