在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VSX1 Antibody

  • 中文名稱:
    VSX1兔多克隆抗體
  • 貨號:
    CSB-PA025938ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: VSX1 antibody IgG at 2.32μg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 39, 25, 40, 15, 30, 23, 25, 33 kDa
      Observed band size: 39 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VSX1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    VSX1
  • 別名:
    VSX1 antibody; RINX antibody; Visual system homeobox 1 antibody; Homeodomain protein RINX antibody; Retinal inner nuclear layer homeobox protein antibody; Transcription factor VSX1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Visual system homeobox 1 protein (1-170AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development. Dispensable in early retinal development.
  • 基因功能參考文獻:
    1. In this study, we added one novel missense sequence variation (p.Arg131Pro) in the coding region of the VSX1 gene to the range of VSX1 coding region variations observed in patients with sporadic keratoconus from China. PMID: 28950846
    2. The aim of this study was to screen the visual system homeobox 1 (VSX1) gene in Turkish patients with keratoconus PMID: 27819732
    3. We cannot confirm the previously reported association of the polymorphism in the VSX1 gene with keratoconus (KC). Our results suggest a possible causative role of SOD1 in the pathogenesis of KC. PMID: 24099280
    4. novel missense substitutions in the VSX1 gene: clinical and genetic analysis of families with Keratoconus from India PMID: 25963163
    5. Our findings confirmed previous reports that polymorphisms of VSX1 and IL1A genes were associated with risk of keratoconus in the Chinese population PMID: 23289806
    6. Our investigation showed that Keratoconus-related VSX1 mutations were found in a very small proportion of the studied patients from Iran. PMID: 24107477
    7. This study reports the presence of pathogenic mutations in VSX1 in posterior polymorphous dystrophy and keratoconus. PMID: 23592923
    8. lack of VSX1 pathogenic variations in a large number of unrelated sporadic keratoconus patients tend to omit its role, and corroborate the involvement of other genetic, environmental or behavioural factors in the development of this complex disorder PMID: 23506487
    9. Our results suggest that the VSX1 gene and its mutations with amino acid changes do not play a major role in the pathogenesis of keratoconus. PMID: 22531431
    10. A significant association between keratoconus patients and VSX1 genetic alterations, is reported. PMID: 22171159
    11. A novel mutation p.G239R and previously reported mutations were found in VSX1 in Italian patients with keratoconus. PMID: 21976959
    12. VSX1 may have an important role in the pathogenesis of keratoconus. PMID: 21365019
    13. In the keratoconus cohort, no pathogenic VSX1 mutation(s) were identified. PMID: 21403853
    14. VSX1has a minor role in keratoconus pathogenesis. PMID: 19763142
    15. In mice, Vsx1 mRNA, protein or reporter gene expression is not detected in the normal or damaged cornea. PMID: 21437200
    16. No pathogenic VSX1 mutation was identified. PMID: 21139977
    17. The absence of pathogenic mutations in VSX1 gene in our large number of unrelated keratoconus patients indicates that other genetic factors are involved in the development of this disorder PMID: 20664914
    18. The absence of pathogenic mutations in our large number of unrelated patients with KC (keratoconus) indicates that other genetic factors are involved in the development of this disorder. PMID: 20023586
    19. Mutations in VSX1 homeobox gene results in impaired DNA binding and is associated with posterior polymorphous dystrophy and keratoconus PMID: 11978762
    20. The new mutation in the VSX1 (RINX) gene described in this report results in abnormal craniofacial features, absence of the roof of the sella turcica, and anomalous development of the corneal endothelium. PMID: 15051220
    21. Mutational analysis of the VSX1 gene in a series of Italian patients revealed one novel mutation and confirmed an important role played by this gene in a significant proportion of patients affected by keratoconus PMID: 15623752
    22. CHX10 and VSX1 may control retinal bipolar cell specification or differentiation by repressing genes required for the development of other cell types PMID: 15647262
    23. The human VSX1 is required for cone ON bipolar cell function but not for rod and cone OFF bipolar cells, giving a unique example of such a selective heritable retinal defect in humans. PMID: 16384943
    24. The absence of pathogenic mutations in the VSX1 gene in a large number of unrelated KTCN (keratoconus) patients indicates that other genetic factors are involved in the development of this disorder. PMID: 16799019
    25. The results show that VSX1 is expressed in vitro and in vivo during human corneal wound healing, a process in which differentiation of corneal keratocytes into myofibroblasts occurs. PMID: 17122109
    26. We excluded c.432C>G sequence alteration as cause. Involvement of this gene in pathogenesis of keratoconus is likely to be confined to a small number of pedigrees. PMID: 17960127
    27. We cannot confirm the previously reported association of the polymorphism in the VSX1 gene with keratoconus. PMID: 18216574
    28. First documentation of VSX1 expression in human neonatal cornea. Full genomic sequence of VSX1 and coding exons of three other candidate genes were excluded from being pathogenic in original posterior polymorphous corneal dystrophy family. PMID: 18253095
    29. VSX1 gene mutation is associated with keratoconus PMID: 18484309
    30. VSX1 gene variants seem to be significant genetic variants for keratoconus predisposition in unrelated Korean patients. PMID: 18626569
    31. The results exclude VSX1 and SOD1 as potential disease-causing genes in these families and localize a novel gene for keratoconus to a 5.6-Mb interval on 13q32. PMID: 19011015
    32. The absence of pathogenic mutations in the VSX-1 gene in affected family members of 3 pedigrees indicates that other genetic factors are involved in the development of familial Fuchs endothelial corneal dystrophy. PMID: 19507099
    33. This is the first report from the Indian subcontinent exploring the role of VSX1 in the causation of keratoconus. PMID: 19956409

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Keratoconus 1 (KTCN1); Craniofacial anomalies and anterior segment dysgenesis syndrome (CAASDS)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Paired homeobox family
  • 組織特異性:
    In the adult eye, expressed in lens, iris, ciliary body, choroid, optical nerve head and, most strongly, in retina, but not expressed in sclera and cornea. According to PubMed:11978762, expressed in adult retina but not in lens and cornea. Within adult re
  • 數據庫鏈接:

    HGNC: 12723

    OMIM: 148300

    KEGG: hsa:30813

    STRING: 9606.ENSP00000365899

    UniGene: Hs.274264



主站蜘蛛池模板: 五月色丁香婷婷网蜜臀av| 久9re热视频这里只有精品 | 国产亚洲欧洲日韩在线...| 久久热最新网站获取| 国产精品久久久久一区二区三区| 少妇高潮喷水久久久影院| 国产精品网站在线观看免费传媒| 蜜桃视频网站| 精品无码中文字幕在线| 亚洲日韩国产一区二区三区在线 | 欧美3p两根一起进高清免费视频| 亚洲欧洲日产韩国无码| 久久精品av国产一区二区| 性做久久久久久久久| 日韩无码专区| 国语自产拍在线视频中文| 韩日综合成人中文字幕| 亚洲精品久久久久久久蜜桃| 无码人妻丰满熟妇区免费 | 色偷偷亚洲第一成人综合网址| 免费无码又爽又刺激高潮的视频| k频道国产在线观看| 最新国产精品精品视频| 日本免费一区二区三区四区五区| 国产精品自产拍高潮在线观看 | 337p日本欧洲亚洲大胆张筱雨| 国产爆乳无码一区二区麻豆| 国模国产精品嫩模大尺度视频| 精品国产自在现线电影| 乱人伦人妻中文字幕无码 | 欧美嫩交一区二区三区| 丰满少妇高潮惨叫久久久| 久久aaaa片一区二区| 亚洲精品电影院| 日本熟妇hdsex视频| 国产精品久久久一区二区三区| 日日澡夜夜澡人人高潮| 亚洲va天堂va欧美ⅴa在线| 嫩草国产露脸精品国产软件| 草草影院发布页| 欧美亚洲国产精品久久|