在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VSNL1 Antibody

  • 中文名稱:
    VSNL1兔多克隆抗體
  • 貨號:
    CSB-PA025933DSR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA025933DSR2HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) VSNL1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    VSNL1
  • 別名:
    21 kDa CABP antibody; Hippocalcin like protein 3 antibody; Hippocalcin-like protein 3 antibody; HLP 3 antibody; HLP3 antibody; HPCAL 3 antibody; HPCAL3 antibody; HUVISL1 antibody; Neural visinin-like protein 1 antibody; Neural visinin-like type 1 protein antibody; Neurocalcin alpha antibody; NVL 1 antibody; NVL1 antibody; Nvp1 antibody; OZ1 antibody; Ratnvp1 antibody; VILIP antibody; VILIP-1 antibody; Visinin antibody; Visinin like 1 antibody; Visinin like protein 1 antibody; Visinin-like protein 1 antibody; VISL 1 antibody; VISL1 antibody; VISL1_HUMAN antibody; VLP-1 antibody; Vnsl1 antibody; Vsnl1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Visinin-like protein 1 protein (1-191AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.
  • 基因功能參考文獻(xiàn):
    1. Underexpression of VSNL1 is associated with glioblastoma multiforme. PMID: 26683098
    2. These data indicate that VILIP-1 alone or in combination with other AD CSF biomarkers represent a valuable marker for the early diagnosis of AD, recognition of MCI patients at higher risk to develop dementia, and in differentiating AD from LBD. PMID: 26836160
    3. These findings suggest a unique role for cerebrospinal fluid Vilip-1 as a biomarker of entorhinal cortex neuron loss in Alzheimer disease PMID: 26769253
    4. The results suggest that both serum and cerebrospinal fluid levels of VILIP-1 may be one of predictive markers of acute encephalopathy with biphasic seizures. PMID: 24075506
    5. We show for the first time that the C-terminus of VILIP-1, containing Cys187, might represent a novel redox-sensitive motif and that VILIP-1 dimerization and aggregation are hallmarks of amyotrophic lateral sclerosis PMID: 24742816
    6. Results show that in the presence of calcium, N-myristoylation significantly increases the kinetic rate of VILIP adsorption to the membrane. PMID: 25019684
    7. The results showed that the CSF VILIP-1 level had significantly increased in Alzheimer disease patients compared with both normal controls and Lewy body dementia patients. PMID: 23800322
    8. SNPs upstream of SLC2A9 and within VSNL1 showed strongest evidence for association with AD + P when compared with controls. PMID: 22005930
    9. VSNL1 single-nucleotide polymorphisms and pathological changes in VILIP-1 protein expression, possibly occurring during brain development, may contribute to the morphological and functional deficits observed in schizophrenia. PMID: 22832524
    10. Patients with high VSNL-1 expression had significantly poorer prognosis than those with low expression in stage III disease PMID: 22052372
    11. The findings suggest that CSF VILIP-1 and VILIP-1/Abeta42 predict rates of global cognitive decline similarly to tau and tau/Abeta42, and may be useful CSF surrogates for neurodegeneration in early Alzheimer disease. PMID: 22357717
    12. VSNL1 may play a role in the pathophysiology of aldosterone-producing adenomas harboring mutations in the potassium channel KCNJ5 via its antiapoptotic function in response to calcium cytotoxicity and its effect on aldosterone production. PMID: 22331379
    13. Data suggest that CSF VILIP-1 and VILIP-1/Abeta42 offer diagnostic utility for early AD, and can predict future cognitive impairment in cognitively normal individuals similarly to tau and tau/Abeta42, respectively. PMID: 21823155
    14. VILIP-1 forms a dimer in solution independent of Ca(2+) and myristoylation. The dimerization site is composed of residues in EF4 and the loop region between EF3 and EF4, confirmed by mutagenesis. PMID: 21169352
    15. Results show that VILIP-1 regulates the cell surface localization of natriuretic peptide receptor B. PMID: 20079378
    16. A shift in the cellular expression of visinin-like protein 1 has been found in the hipppocampi of schizophrenics, since fewer pyramidal neurons but more interneurons show immunoreactivity. PMID: 11930147
    17. EF-hand motifs in visinin-like protein 1 PMID: 12200122
    18. The interaction of human VILIP1 and VILIP3 with divalent cations was explored using circular dichroism and fluorescence measurement. PMID: 16703469
    19. VILIP-1 is expressed in pancreatic beta-cells. Increased VILIP-1 enhanced insulin secretion in a cAMP-associated manner. Down-regulation of VILIP-1 was accompanied by decreased cAMP accumulation but increased insulin gene transcription PMID: 16731532
    20. Distinct roles of proliferative and invasive phenotypes contributing to neuroblastoma progression which demonstrates that VSNL-1 is important in neuroblastoma metastasis. PMID: 17615261
    21. VILIP-1 expression is silenced by promoter hypermethylation and histone deacetylation in aggressive NSCLC cell lines and primary tumors PMID: 18301774
    22. VILIP-1 and its interaction partner nicotinic receptor alpha4beta2 co-localize in morphologically identified human hippocampal interneurons, the number of which is pathologically up-regulated in schizophrenic brains. PMID: 18691652
    23. VILIP1 constitutively binds to P2X2 receptors and displays enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors PMID: 18922787
    24. Results report that overexpression of VILIP-1 enhances ACh responsiveness, whereas siRNA against VILIP-1 reduces alpha4beta2 nAChR currents of hippocampal neurons. PMID: 19063970
    25. Data may imply the functional contribution of disulfide dimer to the interaction of VILIP-1 with its physiological target(s). PMID: 19065602
    26. Deletion and site-directed mutagenesis combined with in silico transcription factor binding analysis of VSNL1 promoter identified nuclear respiratory factor (NRF)-1/alpha-PAL as a major player in regulating VSNL1 minimal promoter activity. PMID: 19674972
    27. VILIP-1 modulates cAMP-accumulation in C6 glioma cells PMID: 9109541
    28. VILIP-1 expression is associated with group I mGlu receptor-mediated plasticity in the dentate gyrus in vivo PMID: 12681369
    29. VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer disease and promotes cell death and tau phosphorylation in vitro PMID: 11592857
    30. VILIP-1 interacts with cell membrane and actin-based cytoskeleton PMID: 8780737
    31. VILIP-1 modulates cGMP-accumulation in transfected neural cells and cerebellar granule neurons PMID: 11579136
    32. reversibility and stimulus-dependent occurrence of a calcium-myristoyl switch of VILIP-1 in living neurons, enabling them to activate specific targets localized in distinct membrane compartments PMID: 12196554
    33. VILIP-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor PMID: 12202488

    顯示更多

    收起更多

  • 蛋白家族:
    Recoverin family
  • 組織特異性:
    Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 12722

    OMIM: 600817

    KEGG: hsa:7447

    STRING: 9606.ENSP00000295156

    UniGene: Hs.444212



主站蜘蛛池模板: 亚洲国产成人久久综合| 成人精品免费视频在线观看| 免费无码又爽又刺激毛片| 性一交一乱一乱一视频| 国产麻豆剧传媒精品av| 久久影院九九被窝爽爽| 亚洲日本va中文字幕人妖| 精品国偷自产在线视频| 中文在线а√天堂| 日韩精品人妻无码久久影院| 亚洲中文无码mv| 久久亚洲国产成人精品无码区| 欧洲熟妇性色黄| 国产福利男女xx00视频| 国内午夜熟妇又乱又伦| 人人妻人人澡人人爽不卡视频| 熟女无套内射线观56| 亚洲午夜成人精品无码app| 中文字幕乱码熟妇五十中出色欲| 国产婷婷色综合av蜜臀av| 狠狠躁夜夜躁人人爽蜜桃 | 人妻少妇偷人无码视频| 色综合天天综合网国产成人网| 蜜芽久久人人超碰爱香蕉| 国产亚洲精品久久久性色情软件 | 免费大片黄在线观看| 国精品午夜福利视频不卡| 四虎精品国产永久在线观看| 性动态图av无码专区| 国产麻豆成人精品av| 精品亚洲成a人在线观看青青| 狠狠色丁香久久综合| 天天躁日日躁狠狠躁欧美老妇小说| 免费无码一区二区三区蜜桃大| 超级大爆乳奶牛被调教出奶水| 北条麻妃在线一区二区| 最爽无遮挡行房视频| 亚洲国产成人超a在线播放| 初尝黑人嗷嗷叫中文字幕| 亚洲精品国产一区二区贰佰信息网| 国产99久9在线视频 | 传媒|