在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. VRK2 Antibody, FITC conjugated

VRK2 Antibody, FITC conjugated

  • 中文名稱：
    VRK2兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA768235LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) VRK2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    VRK2
  • 別名：
    VRK2; Serine/threonine-protein kinase VRK2; Vaccinia-related kinase 2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase VRK2 protein (317-472AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.; Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.
  • 基因功能參考文獻：
    1. VRK2 is suggested as a candidate gene for neurological disorders through its role in signaling pathway, the neuronal loss and stress response. PMID: 29100046
    2. GSK3beta may inhibit VRK2 catalytic activity by disrupting its flexibility. The inhibition of VRK2 catalytic activity by GSK3beta may also inhibit VRK2-induced degradation of TRiC, which could suppress polyQ-expanded Htt aggregation. PMID: 27377031
    3. The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87). PMID: 27922604
    4. Reduced VRK2 mRNA levels are involved in the underlying mechanisms in schizophrenia spectrum disorders. PMID: 26941264
    5. These data support a model in which vaccinia virus B1 and human VRK2 share additional substrates important for the replication of cytoplasmic poxviruses. PMID: 28515294
    6. we replicated one known signal in PAX8 (2.6 minutes per allele, 95% CI [1.9, 3.2], P = 5.7x10-16) and identified and replicated two novel associations at VRK2 (2.0 minutes per allele, 95% CI [1.3, 2.7], P = 1.2x10-9; and 1.6 minutes per allele, 95% CI [1.1, 2.2], P = 7.6x10-9) PMID: 27494321
    7. The data provides further evidence for the genetic contributions of VRK2 rs2312147 to schizophrenia susceptibility especially in Europeans, while further replication analyses in Asian populations are still needed. [meta-analysis] PMID: 27382989
    8. Our data provide preliminary evidence that the VRK2 gene might play a major role in the development of SCZ in the Northwest Chinese Han population. PMID: 26345874
    9. data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia PMID: 25079070
    10. Findings suggest that ubiquitin-specific protease 25 (USP25) as a VRK2 substrate that acts on TRiC deubiquitination. PMID: 25755282
    11. VRK2 is crucial to regulate the ubiquitination-proteosomal degradation of eukaryotic chaperonin TCP-1 ring complex PMID: 24298020
    12. Low levels of VRK2A causes an increase in mitochondrial Bax protein level, leading to an increase in the release of cytochrome C and caspase activation, detected by PARP processing. PMID: 23449449
    13. Generalized epilepsies implicates susceptibility genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32. PMID: 22949513
    14. This study analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European. PMID: 23102693
    15. Human VRK2 is an active kinase playing a role in regulation of cancer cell invasion through the NFAT pathway and COX-2 expression. PMID: 23105117
    16. VRK2A can form a high molecular size complex with both MEK1 and KSR1; the KSR1 complex assembled and retained by VRK2A in the endoplasmic reticulum can have a modulatory effect on the signal mediated by MAPK,locally affecting the magnitude of its responses PMID: 22752157
    17. Common variants at VRK2 show genome-wide significant association with schizophrenia. PMID: 21791550
    18. Data suggest a role for VRK2A in ErbB2-MAPK signaling. PMID: 20679487
    19. VRK2 induces p53 stabilization by post-translational modification, largely due to threonine 18 phosphorylation in tumor cell lines. PMID: 16704422
    20. human VRK2 interacts specifically with EBV BHRF1 and that the interaction is involved in protecting cells from apoptosis PMID: 16963744
    21. Data show that TAK1 forms a stable complex with JIP1 and regulates the activation of JNK, which in turn determines the cellular stress response to hypoxia; this activation of TAK1-JIP1-JNK is suppressed by vaccinia-related kinase 2. PMID: 17709393
    22. the activity of JIP1-JNK complexes is downregulated by VRK2 in response to interleukin-1beta PMID: 18286207
    23. the downregulation of VRK2 protein levels, as a consequence of p53 accumulation, is thus dependent on the levels of the p300/CBP protein available for transcriptional complexes PMID: 18612383

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein. Nucleus envelope.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CK1 Ser/Thr protein kinase family, VRK subfamily
  • 組織特異性：
    Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, periph
  • 數據庫鏈接：

    HGNC: 12719

    OMIM: 602169

    KEGG: hsa:7444

    STRING: 9606.ENSP00000342381

    UniGene: Hs.715298



主站蜘蛛池模板： 午夜性刺激在线视频免费| 呻吟国产av久久一区二区| 亚洲a综合一区二区三区| 亚洲伊人久久精品酒店| 少妇人妻真实偷人精品视频| 美女露出奶头扒开尿口免费网站| 激情综合激情五月俺也去| 大胸美女污污污www网站| 亚洲精品黑牛一区二区三区| 蜜臀av人妻国产精品建身房| 国产亚洲日本精品成人专区| 午夜免费无码福利视频| 亚洲精品成人网站在线观看 | 亚欧洲精品在线视频免费观看| 精品婷婷色一区二区三区| 成人性无码专区免费视频| 99久久人妻无码精品系列蜜桃| 波多野结衣 黑人| 午夜福利影院私人爽爽| 亚洲中文无码线在线观看| 国模吧无码一区二区三区| 免费人成年激情视频在线观看| 国产成人亚洲综合青青| 一边摸一边做爽的免费视频日本| 开心久久婷婷综合中文字幕| 国产精品自在拍在线播放| 人妻丝袜无码国产一区| 国产又色又爽又刺激在线观看| 欧美freesex黑人又粗又大| www国产亚洲精品久久| 国产成人综合亚洲看片| 欧美老人巨大xxxx做受| 18禁成年免费无码国产| 免费观看国产小粉嫩喷水| 少妇私密推油呻吟在线播放| 狠狠躁夜夜躁人人爽天天不卡| 国产成人无码a区在线| 成人无码a∨电影免费| 久久久久国色av免费看| 国内偷自第一区二区三区| 国产强伦姧在线观看无码|