在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. VPS33B Antibody

VPS33B Antibody

  • 中文名稱：
    VPS33B兔多克隆抗體
  • 貨號：
    CSB-PA025903GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    VPS33B
  • 別名：
    VPS33BVacuolar protein sorting-associated protein 33B antibody; hVPS33B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human VPS33B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes.
  • 基因功能參考文獻：
    1. ARKID syndrome is caused by VPS33B mutation. PMID: 28017832
    2. Vesicular trafficking complexes, containing VPS33B, are a novel class of modifiers of integrin function. PMID: 26399659
    3. Novel splice site mutations in the VPS33B gene were identified in arthrogryposis, renal dysfunction, and cholestasis syndrome in Koreans. PMID: 24917129
    4. Abnormal protein trafficking and impairment in multivesicular bodies maturation in Megakaryocytes underlie the alpha-granule deficiency in Vps33b(fl/fl)-ER(T2) mouse and ARC patients. PMID: 25947942
    5. Case Report: neonate with ARC syndrome and high GGT cholestasis caused by VPS33B heterozygous mutations. PMID: 24782640
    6. Case Report: novel mutations in VPS33B in Chinese patient with arthrogryposis, renal dysfunction and cholestasis syndrome. PMID: 24415890
    7. Our data suggest that the ARC syndrome may result through impaired VIPAS39/SPE-39 and Vps33b-dependent endosomal maturation or fusion. PMID: 23918659
    8. Evidence of genotype-phenotype correlation in ARC syndrome the VPS33B c.1225+5G>C mutation predicts a mild phenotype. PMID: 22753090
    9. VPS16B, similar to its binding partner VPS33B, is essential for megakaryocyte and platelet alpha-granule biogenesis. PMID: 23002115
    10. SPE-39 due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF-stimulated cells PMID: 22677173
    11. encodes a homolog of the class C yeast vacuolar protein sorting gene, that contains a Sec1-like domain important in the regulation of vesicle-to-target SNARE complex formation and subsequent membrane fusion PMID: 15052268
    12. A and B classes reflect the evolution of organelle/tissue-specific functions PMID: 15790593
    13. VPS33B is involved in intracellular vesicle trafficking PMID: 16123220
    14. The present observations indicate that VPS33B deficiency results in abnormal secretion of lamellar granules, which underlies ichthyosis in ARC syndrome. PMID: 18347289
    15. Genetic deletion of ptpA attenuates Mycobacterium tuberculosis growth in human macrophages and identify VPS33B, a regulator of membrane fusion, as a PtpA substrate. PMID: 18474358
    16. We assessed the clinical characteristics and investigated the VPS33B mutations in Korean patients with ARC (arthrogryposis, renal dysfunction, and cholestasis) syndrome. PMID: 19274792

    顯示更多

    收起更多

  • 相關疾病：
    Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1)
  • 亞細胞定位：
    Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome.
  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 組織特異性：
    Ubiquitous; highly expressed in testis and low expression in the lung.
  • 數據庫鏈接：

    HGNC: 12712

    OMIM: 208085

    KEGG: hsa:26276

    STRING: 9606.ENSP00000327650

    UniGene: Hs.745007



主站蜘蛛池模板： 国产女人水真多18毛片18精品| 极品人妻少妇一区二区三区| 永久不封国产av毛片| 欧美牲交a欧美牲交| 色婷婷久久综合中文久久蜜桃av| 欧美牲交a欧美在线| 国产精品高清不卡在线播放| 无码精品人妻一区二区三区漫画| 99久久精品日本一区二区免费| 综合图片亚洲综合网站| 成人亚洲精品久久99狠狠| 香蕉97超级碰碰碰免费公开| 粗大猛烈进出高潮视频| 国产人妖乱国产精品人妖| 午夜天堂精品久久久久| 中文乱码人妻系列一区二区| 乱中年女人伦av二区| 国产超碰人人做人人爱| 131美女爱做视频免费| 国产午夜精品av一区二区| 欧洲熟妇牲交| 在线高清理伦片a| 国产97人妻人人做人碰人人爽| 嫩草国产露脸精品国产软件| 成人小说亚洲一区二区三区| 国产高潮国产高潮久久久| 国产成人无码18禁午夜福利网址| 女人被躁到高潮免费视频软件| 精品亚洲国产成人av在线小说| 国产97色在线 | 亚洲| 99久久久无码国产精品免费| 全黄激性性视频| 国产成人综合久久亚洲精品| 精品无码一区二区三区爱欲九九 | 亚洲国产成人久久综合同性| 成人奭片免费观看| 久久精品国产99国产精品亚洲| 国产日产欧产精品精品蜜芽| 蜜臀性色av免费| 2018天天拍拍天天爽视频| 麻豆av福利av久久av|