在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. VPS26A Antibody

VPS26A Antibody

  • 中文名稱：
    VPS26A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA025898LA11HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA025898LA11HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-PA025898LA11HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) VPS26A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ12930 antibody; HB 58 antibody; HB58 antibody; Hbeta 58 antibody; Hbeta 58 homolog antibody; Hbeta58 antibody; Hbeta58 homolog antibody; hVPS 26 antibody; hVPS26 antibody; MGC94168 antibody; PEP 8A antibody; PEP8A antibody; Vacuolar protein sorting 26 A antibody; Vacuolar protein sorting 26 antibody; Vacuolar protein sorting 26 homolog A antibody; Vacuolar protein sorting 26 homolog A S. pombe antibody; Vacuolar protein sorting 26 homolog A yeast antibody; Vacuolar protein sorting 26 yeast antibody; Vacuolar protein sorting 26 yeast homolog antibody; Vacuolar protein sorting 26A antibody; Vacuolar protein sorting associated protein 26A antibody; Vacuolar protein sorting-associated protein 26A antibody; Vesicle protein sorting 26 antibody; Vesicle protein sorting 26A antibody; VP26A_HUMAN antibody; VPS 26 antibody; VPS 26A antibody; VPS26A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Vacuolar protein sorting-associated protein 26A protein (21-180AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，VPS26A Antibody (CSB-PA025898LA11HU)，的標(biāo)記方式是Non-conjugated。對(duì)于VPS26A Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA025898LB11HU VPS26A Antibody, HRP conjugated ELISA
    FITC CSB-PA025898LC11HU VPS26A Antibody, FITC conjugated
    Biotin CSB-PA025898LD11HU VPS26A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2A (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins.
  • 基因功能參考文獻(xiàn)：
    1. The retromer complex is a highly conserved membrane trafficking assembly composed of three proteins - Vps26, Vps29 and Vps35, which are impaired in neurodegenerative diseases. (Review) PMID: 26965691
    2. Mutagenesis studies coupled with coimmunoprecipitations revealed that retromer-mediated trafficking requires the Env cytoplasmic tail that we show binds directly to retromer components Vps35 and Vps26. PMID: 25393110
    3. This study demonstrated that Genetic variability of VPS26A in parkinsonism. PMID: 25475142
    4. Mutations in the gene composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease. PMID: 24684791
    5. Mutations in VPS26A are not a frequent cause of Parkinson's disease. PMID: 24417787
    6. VPS26A binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnitude, revealing cooperativity in cargo selection. PMID: 25136126
    7. Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function PMID: 22284051
    8. Colocalization of Vps26 paralogues with different endosomally located Rab proteins shows prolonged association of Vps26B-retromer with maturing endosomes relative to Vps26A-retromer. PMID: 21920005
    9. These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1/2 and Vps26-Vps29-Vps35 subcomplexes on endosomal membranes and that SNX1 and SNX2 play interchangeable but essential roles. PMID: 17101778
    10. Membrane recruitment of the cargo-selective retromer subcomplex VPS35/29/26 is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. PMID: 19531583

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome.
  • 蛋白家族：
    VPS26 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12711

    OMIM: 605506

    KEGG: hsa:9559

    STRING: 9606.ENSP00000263559

    UniGene: Hs.499925



主站蜘蛛池模板： 欧美性大战久久久久久| 午夜国人精品av免费看| 国产成人啪精品视频免费网站软件 | 婷婷国产成人精品视频| 午夜福利精品亚洲不卡| 护士av无码在线观看| 精品人伦一区二区三电影| 中文字幕乱码中文乱码777| 国产高清japanese在线播放e| 日本高清在线www3344| 免免费国产aaaaa片| 亚洲午夜国产精品无码老牛影视| 男人扒开女人双腿猛进视频| 偷窥村妇洗澡毛毛多| 国产性色播播毛片| 国产精品xxx在线| 久久久久成人片免费观看r| 久久国产精品人妻丝袜| 久久精品久久久久观看99水蜜桃 | 国产精品亚洲а∨天堂| 国产亚洲精品美女久久久| 国产精品免费一区二区三区四区| 色婷婷五月综合激情中文字幕| 中国少妇内射xxxxx-百度| 国产精品亚洲综合一区二区三区| 国产成人一区二区三区别| 精品无码中文字幕在线| 国语自产拍无码精品视频在线| 在线观看国产午夜福利片| 国产精品久久久一区二区三区| 无码av波多野结衣久久| 亚洲va在线va天堂xxxx中文| 亚洲成成品网站源码中国有限公司| 天天鲁一鲁摸一摸爽一爽| 国产精品国产三级国产普通话| 精品久久久久久中文墓无码| 久久97精品久久久久久久不卡| 亚洲成a人片在线观看中文| 国产清纯在线一区二区www| 国产成人精品a视频免费福利| 无码国产色欲xxxx视频|