在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VIPAS39 Antibody, FITC conjugated

  • 中文名稱:
    VIPAS39兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA888005LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VIPAS39 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    VIPAS39
  • 別名:
    Apical basolateral polarity regulator antibody; FLJ12707 antibody; hSPE-39 antibody; Protein spe-39 homolog antibody; SPE 39 antibody; SPE 39 protein antibody; SPE39 antibody; Uncharacterized protein C14orf133 antibody; vipar antibody; VIPAR_HUMAN antibody; VPS16B antibody; VPS33B interacting protein antibody; VPS33B interacting protein apical basolateral polarity regulator antibody; VPS33B interacting protein involved in polarity and apical protein restriction antibody; VPS33B-interacting protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Spermatogenesis-defective protein 39 homolog protein (1-493AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin.
  • 基因功能參考文獻:
    1. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39 PMID: 28039895
    2. Genetic studies showed a homozygous mutation in the VIPAS39 gene. Making the definite diagnosis of the syndrome is important, while increased risk of mutation in other siblings highlights the importance of prenatal diagnosis. PMID: 26808426
    3. Our data suggest that the ARC syndrome may result through impaired VIPAS39/SPE-39 and Vps33b-dependent endosomal maturation or fusion. PMID: 23918659
    4. VPS16B, similar to its binding partner VPS33B, is essential for megakaryocyte and platelet alpha-granule biogenesis. PMID: 23002115
    5. SPE-39 has an inhibitory effect due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF-stimulated cells PMID: 22677173
    6. SPE-39 homologues are present in RAB5-, RAB7-, and RAB11-positive endosomes where they play a conserved role in lysosomal delivery and probably function via their interaction with the core HOPS complex. PMID: 19109425

    顯示更多

    收起更多

  • 相關疾病:
    Arthrogryposis, renal dysfunction and cholestasis syndrome 2 (ARCS2)
  • 亞細胞定位:
    Cytoplasm. Cytoplasmic vesicle. Early endosome. Recycling endosome. Late endosome. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles (PubMed:19109425).
  • 蛋白家族:
    SPE39 family
  • 數據庫鏈接:

    HGNC: 20347

    OMIM: 613401

    KEGG: hsa:63894

    STRING: 9606.ENSP00000339122

    UniGene: Hs.16157



主站蜘蛛池模板: 青青草免费国产线观720| 国产日产精品久久快鸭的功能介绍| 亚洲高清成人av电影网站| 欧美成人午夜性视频| 国产乱沈阳女人高潮乱叫老 | 亚洲精品无码mⅴ在线观看| 欧美精品黑人粗大| 中文字幕制服丝袜人妻动态图| 伊人久久精品一区二区三区| 天天爽夜夜爽夜夜爽精品视频| 久久久久久久岛国免费观看| 蜜桃av蜜臀av色欲av麻| 国产男女猛烈无遮挡免费视频| 男人扒开添女人下部免费视频| 午夜福利啪啪无遮挡免费| 中文字幕韩国三级理论| 人妻无码一区二区三区四区| 狠狠人妻久久久久久综合| 日韩加勒比一本无码精品| 国产乱人伦偷精精品视频| 亚洲精品自在在线观看| 四虎一区二区成人免费影院网址| 久久久女人与动物群交毛片| 伊人久久大香线蕉综合75| 亚洲精品无码久久久久| 精产国品一二三产区9977| 亚洲国产欧美日韩在线人成| 成人性做爰aaa片免费看不忠| 极品嫩模高潮叫床| 在线观看高清黄网站观看| 中文字幕人成人乱码亚洲电影 | 夜夜春夜夜爽| 亚洲精品乱码久久久久红杏| 蜜桃av亚洲精品一区二区| 国产高清在线精品二区| 狠狠色狠狠色综合日日不卡| 国产亚洲精品福利在线无卡一| 99热久久精里都是精品6| 成年美女黄网站色大免费视频 | 日韩av无码免费播放| 国内少妇偷人精品免费|