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VAMP1 Antibody, FITC conjugated

  • 中文名稱：
    VAMP1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA025780LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) VAMP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    VAMP1
  • 別名：
    VAMP1; SYB1; Vesicle-associated membrane protein 1; VAMP-1; Synaptobrevin-1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Vesicle-associated membrane protein 1 protein (1-96AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the targeting and/or fusion of transport vesicles to their target membrane.
  • 基因功能參考文獻(xiàn)：
    1. VAMP1 homozygous mutations causes of presynaptic congenital myasthenic syndrome. PMID: 28253535
    2. residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates. PMID: 25010769
    3. Genetically regulated VAMP1 expression in the brain may modify both Alzheimer's disease risk and may contribute to Alzheimer's pathophysiology PMID: 25881291
    4. This report identifies vesicle-associated membrane protein 1 (VAMP1), which encodes a critical protein for synaptic exocytosis, as the responsible gene fora dominantly inherited spastic ataxia PMID: 22958904
    5. multiple domains outside the R-SNARE of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion PMID: 21330375

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  • 相關(guān)疾?。?/div>
    Spastic ataxia 1, autosomal dominant (SPAX1)
  • 亞細(xì)胞定位：
    [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.; [Isoform 2]: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.; [Isoform 3]: Mitochondrion outer membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    Synaptobrevin family
  • 組織特異性：
    Nervous system, skeletal muscle and adipose tissue.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12642

    OMIM: 108600

    KEGG: hsa:6843

    STRING: 9606.ENSP00000379602

    UniGene: Hs.20021



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