在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VAC14 Antibody, Biotin conjugated

  • 中文名稱:
    VAC14兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA600170LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VAC14 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    VAC14
  • 別名:
    ArPIKfyve antibody; FLJ10305 antibody; FLJ36622 antibody; FLJ46582 antibody; MGC149815 antibody; MGC149816 antibody; OTTHUMP00000174908 antibody; Protein VAC14 homolog antibody; Tax1 (human T cell leukemia virus type I) binding protein 1 antibody; Tax1 (human T cell leukemia virus type I) binding protein 2 antibody; Tax1 binding protein 2 antibody; Tax1-binding protein 2 antibody; TAX1BP2 antibody; TRX antibody; VAC 14 antibody; vac14 antibody; Vac14 homolog (S. cerevisiae) antibody; Vac14 homolog antibody; VAC14_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein VAC14 homolog protein (333-523AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
  • 基因功能參考文獻:
    1. The association data demonstrated strong correlations between rs8060947 and VAC14 expression and between rs8060947 and S. Typhi invasion. The direction of effects for the different alleles led to the hypothesis that reducing VAC14 expression would increase S. Typhi invasion. PMID: 28827342
    2. A genome-wide association study of a prospectively enrolled patient cohort identified an single nucleotide polymorphism in VAC14 that predicts sensitivity to docetaxel-induced peripheral neuropathy. PMID: 27143689
    3. Biallelic rare coding variants in VAC14 was identified in a female neonate with Yunis-Varon syndrome. Cultured patient fibroblasts exhibited a YVS-like vacuolation ameliorated by ML-SA1. PMID: 28635952
    4. The similar age of onset and neurological decline in the two unrelated children define a recessive disorder resulting from compound heterozygosity for deleterious variants of VAC14. PMID: 27292112
    5. Rab7 GAP TBC1D15 with Vac14. PMID: 24578385
    6. a novel regulatory mechanism whereby ArPIKfyve enhances Sac3 abundance by attenuating Sac3 proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J. PMID: 20630877
    7. the PIKfyve-associated hVac14 protein has a major role in activating PIKfyve and thereby regulating PtdIns(3,5)P(2) synthesis and endomembrane homeostasis in mammalian cells PMID: 15542851
    8. describe a novel interaction between the PDZ domain of nitric oxide synthase and Vac14 PMID: 17161399
    9. demonstrate a coupling between the machinery for PtdIns(3,5)P2 synthesis and turnover achieved through a physical assembly of PIKfyve, ArPIKfyve, and Sac3. PMID: 17556371
    10. The authors data indicate that the PAS complex is organized to provide optimal PIKfyve functionality and is maintained via ArPIKfyve homomeric and heteromeric interactions. PMID: 18950639
    11. PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis PMID: 19840946

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Striatonigral degeneration, childhood-onset (SNDC)
  • 亞細胞定位:
    Endosome membrane. Microsome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
  • 蛋白家族:
    VAC14 family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 25507

    OMIM: 604632

    KEGG: hsa:55697

    STRING: 9606.ENSP00000261776

    UniGene: Hs.445061



主站蜘蛛池模板: 先锋影音人妻啪啪va资源网站| 区二区三区玖玖玖| 亚洲综合色区另类小说 | 天堂网www在线资源中文| 日本两人免费观看的视频| 色偷偷久久一区二区三区| 亚洲最大成人网站| 开心五月色婷婷综合开心网| 国产嘿嘿嘿视频在线观看| 丰满无码人妻热妇无码区| 性xxxx18免费观看视频| 日本老妇人乱xxy| 99久久精品午夜一区二区| 久久亚洲精品国产精品婷婷| 国精产品蘑菇一区一区有限| 国产成人av综合色| www.-级毛片线天内射视视| 毛片免费观看天天干天天爽| 亚洲欧洲日韩综合久久| 老鲁夜夜老鲁| 无码国模国产在线观看免费| 人妻无码手机在线中文| 久久久久99精品成人片试看| 精品 日韩 国产 欧美 视频| 少妇做爰又色又紧夜视频| 日本www网站色情乱码| 337p日本欧洲亚洲大胆| 色综合色欲色综合色综合色综合r| 美女视频黄又黄又免费| 亚洲综合色区中文字幕| 插插无码视频大全不卡网站| 麻豆果冻精东九一传媒mv| 国产又粗又硬又大爽黄老大爷| 欧美男男大粗吊1069| 亚洲精品一品区二品区三品区| 亚洲性夜夜综合久久7777| 粗大猛烈进出高潮视频| 欧美日韩午夜群交多人轮换| 亚洲人成精品久久久久桥| 一区二区三区四区在线 | 欧洲| 国产午夜亚洲精品国产成人小说|