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  4. UXS1 Antibody

UXS1 Antibody

  • 中文名稱：
    UXS1兔多克隆抗體
  • 貨號：
    CSB-PA822754LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: JK whole cell lysate(20μg), HepG2 whole cell lysate(20μg), PC-3 whole cell lysate(20μg), A375 whole cell lysate(20μg)
      All lanes: UXS1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 48,49,29 kDa
      Observed band size: 70-100 kDa
      Exposure time: 120s
    • IHC image of CSB-PA822754LA01HU diluted at 1:50 and staining in paraffin-embedded human Lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • IHC image of CSB-PA822754LA01HU diluted at 1:50 and staining in paraffin-embedded human Stomach tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UXS1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UXS1
  • 別名：
    UXS1 antibody; UNQ2538/PRO6079 antibody; UDP-glucuronic acid decarboxylase 1 antibody; EC 4.1.1.35 antibody; UDP-glucuronate decarboxylase 1 antibody; UGD antibody; UXS-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human UDP-glucuronic acid decarboxylase 1 protein (201-420AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，UXS1 Antibody (CSB-PA822754LA01HU)，的標記方式是Non-conjugated。對于UXS1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA822754LB01HU UXS1 Antibody, HRP conjugated ELISA
    FITC CSB-PA822754LC01HU UXS1 Antibody, FITC conjugated
    Biotin CSB-PA822754LD01HU UXS1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
  • 基因功能參考文獻：
    1. The persistence of a latent hexamer-building interface in the human enzyme suggests that the ancestral UXS may have been a hexamer. PMID: 25521717
    2. hUXS forms a tetramer in solution that is important for activity. The higher activity of the tetramer coupled with the relative instability of the dimeric complex suggests that an association-dissociation mechanism may regulate hUXS activity. PMID: 23656592
    3. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. PMID: 11877387
    4. Complementation was achieved by expression of a cytoplasmic variant of UDP-xylose Synthase, which proves the existence of a functional Golgi UDP-xylose transporter[UDP-xylose Synthase] PMID: 19028698
  • 亞細胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    NAD(P)-dependent epimerase/dehydratase family, UDP-glucuronic acid decarboxylase subfamily
  • 數據庫鏈接：

    HGNC: 17729

    OMIM: 609749

    KEGG: hsa:80146

    STRING: 9606.ENSP00000387019

    UniGene: Hs.469561



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