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  4. USP47 Antibody, HRP conjugated

USP47 Antibody, HRP conjugated

  • 中文名稱：
    USP47兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA856964LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) USP47 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    USP47
  • 別名：
    Deubiquitinating enzyme 47 antibody; TFRP antibody; Trf TATA binding protein related factor proximal homolog antibody; Trf TATA binding protein related factor proximal homolog Drosophila antibody; Ubiquitin carboxyl-terminal hydrolase 47 antibody; Ubiquitin specific peptidase 47 antibody; Ubiquitin specific processing protease 47 antibody; Ubiquitin specific protease 47 antibody; Ubiquitin thioesterase 47 antibody; Ubiquitin thiolesterase 47 antibody; Ubiquitin-specific-processing protease 47 antibody; UBP47_HUMAN antibody; USP47 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 47 protein (1-157AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
  • 基因功能參考文獻：
    1. these results suggest that USP47 may play distinct roles in ubiquitin-mediated cellular processes via de-ubiquitinating enzymes activity. PMID: 26115687
    2. miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A. PMID: 25429829
    3. USP47 is a deubiquitinase that prevents beta-catenin ubiquitination. PMID: 26169834
    4. Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47. PMID: 25253721
    5. The results of this study indicated that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. PMID: 23904609
    6. USP47 has a role in regulating DNA repair and maintaining genome integrity PMID: 21362556
    7. USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies. PMID: 19966869

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Expressed in skeletal muscle, heart and testis.
  • 數據庫鏈接：

    HGNC: 20076

    OMIM: 614460

    KEGG: hsa:55031

    STRING: 9606.ENSP00000339957

    UniGene: Hs.577256



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